Rabbit anti-Human, Mouse RPC5 Polyclonal Antibody | anti-RPC5 antibody

RPC5 Antibody

Cat. Num. AAA9506299

• Gene Names: POLR3E; SIN; RPC5
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Immunofluorescence, ELISA
• Purity: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Synonyms: RPC5; Polyclonal Antibody; RPC5 Antibody; DNA-directed RNA polymerase III subunit RPC5; RNA polymerase III subunit C5; DNA-directed RNA polymerase III 80 kDa polypeptide; anti-RPC5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: RPC5 Antibody detects endogenous levels of total RPC5 protein.
• Purity/Purification: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 672

• Applicable Applications for anti-RPC5 antibody: Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
• Application Notes: IHC: 1:50~1:100; IF: 1:100~1:500; ELISA: 1:40000
• Target Modification: Unmodified/Total
• Immunogen: The antiserum was produced against synthesized peptide derived from human RPC5.
• Immunogen Range: 191-240
• Preparation and Storage: Stable at -20 degree C for at least 1 year.

Immunofluorescence (IF)

(Immunofluorescence analysis of LOVO cells, using RPC5 Antibody. The picture on the right is blocked with the synthesized peptide.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using RPC5 Antibody. The picture on the right is blocked with the synthesized peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 384475535
• NCBI GeneID: 55718
• NCBI Accession #: NP_001244962.1
• NCBI GenBank Nucleotide #: NM_001258033.1
• UniProt Accession #: Q9NVU0; Q9BWF7; Q9H8W8; Q9H907; Q9P276; B4DL24; B4DUP6; H3BT11
• Molecular Weight: 79 kDa
• NCBI Official Full Name: DNA-directed RNA polymerase III subunit RPC5 isoform 2
• NCBI Official Synonym Full Names: RNA polymerase III subunit E
• NCBI Official Symbol: POLR3E
• NCBI Official Synonym Symbols: SIN; RPC5
• NCBI Protein Information: DNA-directed RNA polymerase III subunit RPC5
• UniProt Protein Name: DNA-directed RNA polymerase III subunit RPC5
• UniProt Gene Name: POLR3E
• UniProt Synonym Gene Names: KIAA1452; RNA polymerase III subunit C5

Uniprot Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway ().