Rabbit RPAIN Polyclonal Antibody | anti-RPAIN antibody

Rabbit Polyclonal to Human RPAIN

Cat. Num. AAA241312

• Gene Names: RPAIN; RIP; HRIP
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: RPAIN; Polyclonal Antibody; Rabbit Polyclonal to Human RPAIN; Anti-RPAIN Antibody (C-Terminus) IHC-plus; HRIP; RPA interacting protein; RIP; RAP interaction protein; RPA-interacting protein; Nuclear transporter; Human RPAIN; anti-RPAIN antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: 17 amino acid peptide from near the carboxy terminus of human RPA IP.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 81195210

• Applicable Applications for anti-RPAIN antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human RPAIN.
• Immunogen Type: Synthetic peptide
• Immunogen: RPAIN antibody was raised against synthetic peptide from human RPAIN.
• Antigen Modification: C-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-RPAIN antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of RPA Interacting Protein in Jurkat cell lysate with RPA Interacting Protein antibody at (A) 0.5 and (B) 1 ug/ml.)

Product Categories/Family for anti-RPAIN antibody

Family: Transporter

NCBI and Uniprot Product Information

• NCBI GI #: 224589808
• NCBI GeneID: 84268
• NCBI Accession #: NC_000017.10
• NCBI GenBank Nucleotide #: NC_000017.10
• Molecular Weight: 17,118 Da
• NCBI Official Full Name: Homo sapiens chromosome 17, GRCh37.p13 Primary Assembly
• NCBI Official Synonym Full Names: RPA interacting protein
• NCBI Official Symbol: RPAIN
• NCBI Official Synonym Symbols: RIP; HRIP
• NCBI Protein Information: RPA-interacting protein; nuclear transporter; RAP interaction protein
• UniProt Protein Name: RPA-interacting protein
• Protein Family: RPA-interacting protein
• UniProt Gene Name: RPAIN
• UniProt Synonym Gene Names: RIP; hRIP
• UniProt Entry Name: RIP_HUMAN

Uniprot Description

RPAIN: Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage; DNA replication

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: PML body; cytoplasm; nucleolus; nucleus

Molecular Function: metal ion binding; protein complex binding

Biological Process: protein import into nucleus; DNA-dependent DNA replication; DNA repair; response to UV; DNA recombination