Rabbit ROR2 Polyclonal Antibody | anti-ROR2 antibody

ROR2 Antibody

Cat. Num. AAA9405747

• Gene Names: ROR2; BDB; BDB1; NTRKR2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: ROR2; Polyclonal Antibody; ROR2 Antibody; BDB; BDB1; NTRKR2; anti-ROR2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total ROR2 protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 943

• Applicable Applications for anti-ROR2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:50 - 1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human ROR2.
• Target Name: ROR2
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using ROR2 antibody.)

Related Product Information for anti-ROR2 antibody

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.

Product Categories/Family for anti-ROR2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 19743898
• NCBI GeneID: 4920
• NCBI Accession #: NP_004551.2
• NCBI GenBank Nucleotide #: NM_004560.3
• UniProt Accession #: Q01974; Q59GF5; Q5SPI5; Q9HAY7; Q9HB61
• Molecular Weight: 104,757 Da
• NCBI Official Full Name: tyrosine-protein kinase transmembrane receptor ROR2
• NCBI Official Synonym Full Names: receptor tyrosine kinase-like orphan receptor 2
• NCBI Official Symbol: ROR2
• NCBI Official Synonym Symbols: BDB; BDB1; NTRKR2
• NCBI Protein Information: tyrosine-protein kinase transmembrane receptor ROR2
• UniProt Protein Name: Tyrosine-protein kinase transmembrane receptor ROR2
• UniProt Gene Name: ROR2
• UniProt Synonym Gene Names: NTRKR2
• UniProt Entry Name: ROR2_HUMAN

NCBI Description

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]

Uniprot Description

ROR2: a receptor tyrosine kinase of the ROR family. May be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.

Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Protein kinase, TK; TK group; Ror family

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: Wnt-protein binding; protein binding; frizzled binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: somitogenesis; inner ear morphogenesis; peptidyl-tyrosine phosphorylation; Wnt receptor signaling pathway, planar cell polarity pathway; multicellular organismal development; positive regulation of transcription, DNA-dependent; signal transduction; negative regulation of cell proliferation; Wnt receptor signaling pathway, calcium modulating pathway; JNK cascade; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; cartilage condensation; embryonic genitalia morphogenesis

Disease: Robinow Syndrome, Autosomal Recessive; Brachydactyly, Type B1