Rabbit Robo3 Polyclonal Antibody | anti-Robo3 antibody
Robo3 Antibody BIOTIN-Conjugated
ELISA: 1:10,000
Western Blot: 1:500
ostsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release.
NCBI and Uniprot Product Information
NCBI Description
binds specifically to metabotropic glutamate receptor; may regulate metabotropic glutamate signaling [RGD, Feb 2006]
Uniprot Description
HOMER1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Interacts with IFT57. Interacts with OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. Belongs to the Homer family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Contractile; Cell adhesion; Cell development/differentiation
Cellular Component: apical part of cell; axon; cell junction; cell soma; costamere; cytoplasm; dendrite; dendritic shaft; excitatory synapse; membrane; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; synapse; Z disc
Molecular Function: identical protein binding; metabotropic glutatmate receptor binding; protein binding; protein complex scaffold; protein heterodimerization activity; receptor binding; type 5 metabotropic glutamate receptor binding
Biological Process: behavioral response to cocaine; chemical homeostasis within a tissue; circadian rhythm; metabotropic glutamate receptor signaling pathway; positive regulation of calcium ion transport; response to calcium ion; response to cocaine; response to nicotine; skeletal muscle contraction; skeletal muscle fiber development
Research Articles on Robo3
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Product Notes
The Robo3 homer1 (Catalog #AAA544707) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Robo3 Antibody BIOTIN-Conjugated reacts with Bovine, Human, Monkey, Panda and may cross-react with other species as described in the data sheet. AAA Biotech's Robo3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Western Blot: 1:500. Researchers should empirically determine the suitability of the Robo3 homer1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Robo3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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