Rabbit anti-Human RILP Polyclonal Antibody | anti-RILP antibody

RILP Rabbit Polyclonal

Cat. Num. AAA7603531

• Gene Names: RILP; PP10141
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RILP; Polyclonal Antibody; RILP Rabbit Polyclonal; anti-RILP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 401

• Applicable Applications for anti-RILP antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Immunogen: Rab interacting lysosomal protein
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS7603531 (RILP Antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 93204881
• NCBI GeneID: 83547
• NCBI Accession #: NP_113618.2
• NCBI GenBank Nucleotide #: NM_031430.2
• Molecular Weight: 20,726 Da
• NCBI Official Full Name: rab-interacting lysosomal protein
• NCBI Official Synonym Full Names: Rab interacting lysosomal protein
• NCBI Official Symbol: RILP
• NCBI Official Synonym Symbols: PP10141
• NCBI Protein Information: rab-interacting lysosomal protein
• UniProt Protein Name: Rab-interacting lysosomal protein
• Protein Family: RILP-like protein
• UniProt Gene Name: RILP
• UniProt Entry Name: RILP_HUMAN

NCBI Description

This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011]

Uniprot Description

RILP: Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cytosol; late endosome; late endosome membrane; lysosomal membrane; lysosome; mitochondrion; phagocytic vesicle membrane; protein complex

Molecular Function: dynein light intermediate chain binding; protein binding; Rab GTPase binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; early endosome to late endosome transport; endosome to lysosome transport; endosome transport via multivesicular body sorting pathway; negative regulation of protein catabolic process; positive regulation of protein catabolic process; protein transport