Immunohistochemistry (IHC)
(RIC3 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RIC3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human RIC3 Polyclonal Antibody | anti-RIC3 antibody
RIC3 Antibody (C-term)
WB~~1:1000
Immunohistochemistry (IHC)
(RIC3 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RIC3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(RIC3 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RIC3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Western Blot (WB)
(RIC3 Antibody (C-term) western blot analysis in NCI-H292,A549,WiDr,MDA-MB453 cell line lysates (35ug/lane).This demonstrates the RIC3 antibody detected the RIC3 protein (arrow).)
Western Blot (WB)
(RIC3 Antibody (C-term) western blot analysis in NCI-H292,A549,WiDr,MDA-MB453 cell line lysates (35ug/lane).This demonstrates the RIC3 antibody detected the RIC3 protein (arrow).)
receptors (nAChRs), neurotransmitter-gated ion channels expressed
at the neuromuscular junction and within the central and peripheral
nervous systems, that can enhance functional expression of multiple
nAChR subtypes (Lansdell et al., 2005 [PubMed 16120769]).[supplied
by OMIM].
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Seredenina, T., et al. Biosci. Rep. 28(6):299-306(2008)
Roncarati, R., et al. Assay Drug Dev Technol 6(2):181-193(2008)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene promotes functional expression of homomeric nicotinic acetylcholine receptors at the cell surface. It enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Description
RIC3: Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5- HT3 receptors, and of heteromeric acetylcholine receptors alpha- 3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. Belongs to the ric-3 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane
Molecular Function: acetylcholine receptor binding
Biological Process: elevation of cytosolic calcium ion concentration; cellular protein complex assembly; protein folding; synaptic transmission, cholinergic
Research Articles on RIC3
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Product Notes
The RIC3 ric3 (Catalog #AAA9203305) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 313-341. The RIC3 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RIC3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB). IHC~~1:10~50 WB~~1:1000. Researchers should empirically determine the suitability of the RIC3 ric3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RIC3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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