Rabbit anti-Human, Mouse ANXA3 Polyclonal Antibody | anti-ANXA3 antibody

ANXA3, ID (Annexin A3, Annexin-3, Annexin III, Lipocortin III, Placental Anticoagulant Protein III, PAP-III, 35-alpha Calcimedin, Inositol 1,2-cyclic Phosphate 2-phosphohydrolase, ANX3) (FITC)

Cat. Num. AAA6463266

• Gene Names: ANXA3; ANX3
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Ammonium Sulfate Precipitation.
• Synonyms: ANXA3; Polyclonal Antibody; ID (Annexin A3; Annexin-3; Annexin III; Lipocortin III; Placental Anticoagulant Protein III; PAP-III; 35-alpha Calcimedin; Inositol 1; 2-cyclic Phosphate 2-phosphohydrolase; ANX3) (FITC); anti-ANXA3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human ANXA3. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Ammonium Sulfate Precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-ANXA3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:50-1:100; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-terminal region of human ANXA3 (KLH).
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of anti-ANXA3 Antibody (Center) in mouse lung tissue lysates (35ug/lane). ANXA3(arrow) was detected using the purified Pab.)

Product Categories/Family for anti-ANXA3 antibody

Antibodies; Annexin

References

1. Park, J.E., Biochem. Biophys. Res. Commun. 337(4), 1283-1287 (2005). 2. Bodeker, H., Mol. Cell Biol. Res. Commun. 2(3), 150-154 (1999).

NCBI and Uniprot Product Information

• NCBI GI #: 4826643
• NCBI GeneID: 306
• NCBI Accession #: NP_005130
• NCBI GenBank Nucleotide #: NM_005139.2
• UniProt Accession #: P12429; Q6LET2; B2R9W6
• Molecular Weight: 36.3 kDa (323aa), confirmed by MALDI-TOF.
• NCBI Official Full Name: annexin A3
• NCBI Official Synonym Full Names: annexin A3
• NCBI Official Symbol: ANXA3
• NCBI Official Synonym Symbols: ANX3
• NCBI Protein Information: annexin A3
• UniProt Protein Name: Annexin A3
• Protein Family: Annexin
• UniProt Gene Name: ANXA3
• UniProt Synonym Gene Names: ANX3; PAP-III
• UniProt Entry Name: ANXA3_HUMAN

NCBI Description

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]

Uniprot Description

ANXA3: a calcium/phospholipid-binding protein and inhibitor of phospholipase A2, Possesses anti-coagulant properties. Cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 4q21.21

Cellular Component: specific granule; phagocytic vesicle membrane; membrane; cytoplasm; plasma membrane

Molecular Function: calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; calcium ion binding; calcium-dependent protein binding

Biological Process: positive regulation of angiogenesis; negative regulation of catalytic activity; neutrophil degranulation; defense response to bacterium; positive regulation of transcription factor activity; phagocytosis