Rabbit anti-Human Rhes Polyclonal Antibody | anti-RASD2 antibody

Rhes, CT (RASD2, GTP-binding Protein Rhes, Ras Homolog Enriched in Striatum, Tumor Endothelial Marker 2, TEM2)

Cat. Num. AAA6002280

• Gene Names: RASD2; Rhes; TEM2; MGC:4834
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Rhes; Polyclonal Antibody; CT (RASD2; GTP-binding Protein Rhes; Ras Homolog Enriched in Striatum; Tumor Endothelial Marker 2; TEM2); Anti -Rhes; anti-RASD2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human Rhes. Species Crossreactivity
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.

• Applicable Applications for anti-RASD2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Western Blot: 1:500; Immunohistochemistry: 1:500
• Immunogen: Synthetic linear peptide corresponding to C-terminal of human Rhes (KLH).
• Positive Control: Human pancreas tissue lysate; ; Storage and Stability:; May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Preparation and Storage: -20 degree C

Related Product Information for anti-RASD2 antibody

Ras family proteins are molecular switches, which are mediated by extracellular signals and regulate intracellular signaling pathways, thereby controlling a plethora of biological functions such as cell growth, gene transcription, mRNA stability and translation, cytoskeleton organization, peptide trafficking and secrection. Ras proteins are also involved in synaptic plasticity, learning, and memory in the central nervous system. As a member of the RASD subfamily of the Ras-related GTP-binding protein superfamily, Rhes is predominantly expressed in the striatal region of the brain, where it reported to influence brain development and function. It is thought that the activation and expression of the Rhes gene is mediated by thyroid hormones in the brain. In humans, a lack of such hormones is known to cause cretinism. Additionally, Rhes -/- knockout mice display marked behavioral abnormalities, a gender-dependent increase in anxiety levels, and a clear deficit in motor coordination.

Product Categories/Family for anti-RASD2 antibody

Antibodies; Abs to Cancer Markers

NCBI and Uniprot Product Information

• NCBI GI #: 15426591
• NCBI GeneID: 23551
• UniProt Accession #: Q96D21; O95520; Q5THY8
• Molecular Weight: 30,366 Da
• NCBI Official Full Name: RASD family, member 2
• NCBI Official Synonym Full Names: RASD family, member 2
• NCBI Official Symbol: RASD2
• NCBI Official Synonym Symbols: Rhes; TEM2; MGC:4834
• NCBI Protein Information: GTP-binding protein Rhes; tumor endothelial marker 2; Ras homolog enriched in striatum
• UniProt Protein Name: GTP-binding protein Rhes
• Protein Family: Rhesus theta defensin
• UniProt Gene Name: RASD2
• UniProt Synonym Gene Names: TEM2
• UniProt Entry Name: RHES_HUMAN

NCBI Description

This gene encodes a Ras-related protein that enriched in striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades. [provided by RefSeq, Jul 2008]

Uniprot Description

RASD2: GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. Belongs to the small GTPase superfamily. RasD family.

Protein type: G protein, monomeric; G protein; G protein, monomeric, RasD

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: plasma membrane

Molecular Function: GTPase activity; GTP binding; ubiquitin conjugating enzyme binding; G-protein beta-subunit binding

Biological Process: positive regulation of protein sumoylation; positive regulation of protein kinase B signaling cascade; synaptic transmission, dopaminergic; metabolic process; small GTPase mediated signal transduction; negative regulation of protein ubiquitination; locomotory behavior