Rabbit RGS7 Polyclonal Antibody | anti-RGS7 antibody

RGS7 Rabbit Polyclonal

Cat. Num. AAA7603506

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RGS7; Polyclonal Antibody; RGS7 Rabbit Polyclonal; anti-RGS7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 477

• Applicable Applications for anti-RGS7 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Regulator of G-protein signaling 7
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gliomas using MBS7603506 (RGS7 antibody) at dilution of 1:50)

Western Blot (WB)

(SH-SY5Y cells were subjected to SDS PAGE followed by western blot with MBS7603506 (RGS7 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 544346265
• NCBI GeneID: 6000
• NCBI Accession #: NP_001269704.1
• NCBI GenBank Nucleotide #: NM_001282775.1
• Molecular Weight: 56,741 Da
• NCBI Official Full Name: regulator of G-protein signaling 7 isoform 3
• NCBI Official Synonym Full Names: regulator of G-protein signaling 7
• NCBI Official Symbol: RGS7
• NCBI Protein Information: regulator of G-protein signaling 7
• UniProt Protein Name: Regulator of G-protein signaling 7
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS7
• UniProt Synonym Gene Names: RGS7
• UniProt Entry Name: RGS7_HUMAN

Uniprot Description

RGS7: inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations. Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity). Interacts with 14-3-3 protein Tau and SNAP25BP. Four alternatively spliced isoforms have been described.

Protein type: GAPs; GAPs, RGS

Chromosomal Location of Human Ortholog: 1q43|1q23.1

Cellular Component: cytosol; heterotrimeric G-protein complex; plasma membrane

Molecular Function: G-protein beta-subunit binding; GTPase activator activity; signal transducer activity

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of signal transduction; positive regulation of GTPase activity; protein folding