Rabbit anti-Human RGS12 Polyclonal Antibody | anti-RGS12 antibody

RGS12 Antibody

Cat. Num. AAA7131578

• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: RGS12; Polyclonal Antibody; RGS12 Antibody; regulator of G-protein signaling 12; anti-RGS12 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; Rabbit IgG In Phosphate Buffered Saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol.

• Applicable Applications for anti-RGS12 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:3000
• Immunogen: Synthesized peptide derived from N-terminal of human RGS12.
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blot analysis of extracts from 3T3 cells, using RGS12 antibody. )

Product Categories/Family for anti-RGS12 antibody

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 4506509
• NCBI GeneID: 6002
• NCBI Accession #: NP_002917.1
• NCBI GenBank Nucleotide #: NM_002926.3
• UniProt Accession #: O14924; O14922; O14923; O43510; O75338; B1AQ30; B1AQ31; B1AQ32
• Molecular Weight: 156,357 Da
• NCBI Official Full Name: regulator of G-protein signaling 12 isoform 2
• NCBI Official Synonym Full Names: regulator of G-protein signaling 12
• NCBI Official Symbol: RGS12
• NCBI Protein Information: regulator of G-protein signaling 12; regulator of G-protein signalling 12
• UniProt Protein Name: Regulator of G-protein signaling 12
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS12
• UniProt Synonym Gene Names: RGS12
• UniProt Entry Name: RGS12_HUMAN

NCBI Description

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

RGS12: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, misc.

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nuclear matrix; condensed nuclear chromosome; cytoplasm; nucleolus; plasma membrane; nucleus

Molecular Function: receptor signaling protein activity; GTPase regulator activity; GTPase activator activity

Biological Process: transcription, DNA-dependent; regulation of catalytic activity; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity