Rabbit anti-Human RGS11 Polyclonal Antibody | anti-RGS11 antibody

RGS11 (Regulator of G Protein Signaling 11)

Cat. Num. AAA614731

• Gene Names: RGS11; RS11
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified; Purified
• Synonyms: RGS11; Polyclonal Antibody; RGS11 (Regulator of G Protein Signaling 11); Anti -RGS11 (Regulator of G Protein Signaling 11); anti-RGS11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human RGS11
• Purity/Purification: Purified; Purified
• Form/Format: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.

• Applicable Applications for anti-RGS11 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:200-1:1000; observed size: ~48 kD; positive control: human or rat brain whole tissue lysate
• Immunogen: Synthetic peptide corresponding to amino acids 201-218 of human RGS11 (isoform 2).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western Blot analysis of RGS11 in 30ug of rat brain tissue lysate using MBS614731 at 1:1000 dilution.)

Related Product Information for anti-RGS11 antibody

RGS11, regulator of G protein signaling 11, belongs to a subfamily of RGS proteins, which serve as GAPs (GTPase-activating proteins), increasing the rate at which GTP is converted to GDP by isoform alpha G proteins.

Product Categories/Family for anti-RGS11 antibody

Antibodies; Abs to G Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 34452688
• NCBI GeneID: 8786
• NCBI Accession #: NP_899180.1
• NCBI GenBank Nucleotide #: NM_183337.1
• UniProt Accession #: O94810; O75883; Q4TT71; Q4TT70; Q4TT72; Q59F78; Q8IWC5
• Molecular Weight: 52,946 Da
• NCBI Official Full Name: regulator of G-protein signaling 11 isoform 1
• NCBI Official Synonym Full Names: regulator of G-protein signaling 11
• NCBI Official Symbol: RGS11
• NCBI Official Synonym Symbols: RS11
• NCBI Protein Information: regulator of G-protein signaling 11; OTTHUMP00000067354; OTTHUMP00000067355; OTTHUMP00000067356; regulator of G-protein signalling 11
• UniProt Protein Name: Regulator of G-protein signaling 11
• Protein Family: Regulator of G-protein signaling
• UniProt Gene Name: RGS11
• UniProt Entry Name: RGS11_HUMAN

NCBI Description

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]

Uniprot Description

RGS11: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: protein complex; cytoplasm; plasma membrane; heterotrimeric G-protein complex

Molecular Function: signal transducer activity; G-protein beta-subunit binding; GTPase activator activity

Biological Process: G-protein coupled receptor protein signaling pathway; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity