Western Blot (WB)
(RGMA Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RGMA antibody detected the RGMA protein (arrow).)
Rabbit anti-Human RGMA Polyclonal Antibody | anti-RGMA antibody
RGMA Antibody (C-term)
Western Blot (WB)
(RGMA Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RGMA antibody detected the RGMA protein (arrow).)
Western Blot (WB)
(RGMA Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RGMA antibody detected the RGMA protein (arrow).)
molecule family. The encoded protein is a
glycosylphosphatidylinositol-anchored glycoprotein that functions
as an axon guidance protein in the developing and adult central
nervous system. This protein may also function as a tumor
suppressor in some cancers. Alternate splicing results in multiple
transcript variants.
Severyn, C.J., et al. Biochem. J. 422(3):393-403(2009)
Li, V.S., et al. Gastroenterology 137(1):176-187(2009)
Endo, M., et al. J. Neurosci. 29(20):6649-6662(2009)
Hata, K., et al. J. Cell Biol. 184(5):737-750(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Description
RGMA: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. Belongs to the repulsive guidance molecule (RGM) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: endoplasmic reticulum; plasma membrane
Molecular Function: coreceptor activity
Biological Process: BMP signaling pathway; axon guidance
Research Articles on RGMA
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Product Notes
The RGMA rgma (Catalog #AAA9210572) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 390-418. The RGMA Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RGMA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the RGMA rgma for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RGMA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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