Rabbit RGMA Polyclonal Antibody | anti-RGMA antibody

RGMA Rabbit Polyclonal

Cat. Num. AAA7603494

• Gene Names: RGMA; RGM
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RGMA; Polyclonal Antibody; RGMA Rabbit Polyclonal; anti-RGMA antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 434

• Applicable Applications for anti-RGMA antibody: ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
• Immunogen: RGM domain family, member A
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse testis tissue were subjected to SDS PAGE followed by western blot with MBS7603494 (RGMA antibody) at dilution of 1:400)

NCBI and Uniprot Product Information

• NCBI GI #: 261878467
• NCBI GeneID: 56963
• NCBI Accession #: NP_001159761.1
• NCBI GenBank Nucleotide #: NM_001166289.1
• Molecular Weight: 50,035 Da
• NCBI Official Full Name: repulsive guidance molecule A isoform 2
• NCBI Official Synonym Full Names: repulsive guidance molecule family member a
• NCBI Official Symbol: RGMA
• NCBI Official Synonym Symbols: RGM
• NCBI Protein Information: repulsive guidance molecule A
• UniProt Protein Name: Repulsive guidance molecule A
• Protein Family: Repulsive guidance molecule
• UniProt Gene Name: RGMA
• UniProt Synonym Gene Names: RGM
• UniProt Entry Name: RGMA_HUMAN

NCBI Description

This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot Description

RGMA: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. Belongs to the repulsive guidance molecule (RGM) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: endoplasmic reticulum; plasma membrane

Molecular Function: coreceptor activity; glycoprotein binding; protein binding

Biological Process: BMP signaling pathway; positive regulation of transcription from RNA polymerase II promoter