Western Blot (WB)
(RFXAP Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the RFXAP antibody detected the RFXAP protein (arrow).)
Rabbit RFXAP Polyclonal Antibody | anti-RFXAP antibody
RFXAP Antibody (C-term)
Western Blot (WB)
(RFXAP Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the RFXAP antibody detected the RFXAP protein (arrow).)
Western Blot (WB)
(RFXAP Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the RFXAP antibody detected the RFXAP protein (arrow).)
transmembrane proteins that have a central role in development and
control of the immune system. The protein encoded by this gene,
along with regulatory factor X-associated ankyrin-containing
protein and regulatory factor-5, forms a complex that binds to the
X box motif of certain MHC class II gene promoters and activates
their transcription. Once bound to the promoter, this complex
associates with the non-DNA-binding factor MHC class II
transactivator, which controls the cell type specificity and
inducibility of MHC class II gene expression. Mutations in this
gene have been linked to bare lymphocyte syndrome type II,
complementation group D. Transcript variants utilizing different
polyA signals have been found for this gene.
Bushway, M., et al. Immunogenetics 62(2):109-116(2010)
Briggs, L., et al. Proteins 76(3):655-664(2009)
Garvie, C.W., et al. Biochim. Biophys. Acta 1779(12):797-804(2008)
van Eggermond, M.C., et al. Mol. Immunol. 45(10):2920-2928(2008)
NCBI and Uniprot Product Information
NCBI Description
Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
RFXAP: Part of the RFX complex that binds to the X-box of MHC II promoters. Defects in RFXAP are a cause of bare lymphocyte syndrome type 2 (BLS2); also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 13q14
Cellular Component: nucleus
Molecular Function: DNA binding; transcription coactivator activity; transcription factor activity
Biological Process: positive regulation of transcription, DNA-dependent
Disease: Bare Lymphocyte Syndrome, Type Ii
Research Articles on RFXAP
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Product Notes
The RFXAP rfxap (Catalog #AAA9212821) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 196-225. The RFXAP Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's RFXAP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the RFXAP rfxap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RFXAP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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