Western Blot (WB)
(Western blot analysis of REEP1 expression in mouse brain (A), rat brain (B) whole cell lysates.)
Rabbit REEP1 Polyclonal Antibody | anti-REEP1 antibody
Anti-REEP1 Antibody
Western Blot (WB)
(Western blot analysis of REEP1 expression in mouse brain (A), rat brain (B) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of REEP1 expression in mouse brain (A), rat brain (B) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a mitochondrial protein that functions to enhance the cell surface expression of odorant receptors. Mutations in this gene cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Uniprot Description
REEP1: Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors. Defects in REEP1 are the cause of spastic paraplegia autosomal dominant type 31 (SPG31). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Belongs to the DP1 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component: cytoplasm; endoplasmic reticulum; membrane
Molecular Function: microtubule binding; olfactory receptor binding; protein binding
Biological Process: protein insertion into membrane
Disease: Neuronopathy, Distal Hereditary Motor, Type Vb; Spastic Paraplegia 31, Autosomal Dominant
Research Articles on REEP1
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Product Notes
The REEP1 reep1 (Catalog #AAA8247622) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-REEP1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's REEP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1/500 - 1/2000. Researchers should empirically determine the suitability of the REEP1 reep1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "REEP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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