Rabbit anti-Mouse Receptor For Advanced Glycation Endproducts (RAGE) Polyclonal Antibody | anti-RAGE antibody

FITC-Linked Polyclonal Antibody to Receptor For Advanced Glycation Endproducts (RAGE)

Cat. Num. AAA2125816

• Gene Names: Ager; RAGE
• Reactivity: Mouse
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation
• Purity: Affinity Chromatography
• Synonyms: Receptor For Advanced Glycation Endproducts (RAGE); Polyclonal Antibody; FITC-Linked Polyclonal Antibody to Receptor For Advanced Glycation Endproducts (RAGE); RAGE/Receptor For Advanced Glycation Endproducts; AGER; Receptor For Advanced Glycation Endproducts; anti-RAGE antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Specificity: The antibody is a Rabbit polyclonal Antibody raised against Receptor For Advanced Glycation Endproducts (RAGE). It has been selected for its ability to recognize RAGE in immunohistochemical staining and western blotting.
• Purity/Purification: Affinity Chromatography
• Form/Format: Liquid; 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
• Concentration: >=0.5mg/mL (Please refer to the vial label for the specific concentration.) (varies by lot)

• Applicable Applications for anti-RAGE antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
• Application Notes: WB: 0.5-2ug/mL; IHC: 5-20ug/mL; ICC: 5-20ug/mL
• Immunogen: Recombinant proteins/RP
• Organism Species: Mouse
• Conjugation: FITC
• Preparation and Storage: Store at 4 degree C for frequent use, -20 degree C for 24 months; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for anti-RAGE antibody

Metabolic pathway; Tumor immunity; Endocrinology; Cardiovascular biology; Neuro science; Primary, FITC-labeled

NCBI and Uniprot Product Information

• NCBI GI #: 84570471
• NCBI GeneID: 11596
• UniProt Accession #: Q62151
• Molecular Weight: 42,669 Da
• NCBI Official Full Name: endogenous secretory receptor for advanced glycation endproducts
• NCBI Official Synonym Full Names: advanced glycosylation end product-specific receptor
• NCBI Official Symbol: Ager
• NCBI Official Synonym Symbols: RAGE
• NCBI Protein Information: advanced glycosylation end product-specific receptor; advanced glycation end-products receptor; receptor for advanced glycosylation end products
• UniProt Protein Name: Advanced glycosylation end product-specific receptor
• UniProt Gene Name: Ager
• UniProt Synonym Gene Names: Rage
• UniProt Entry Name: RAGE_MOUSE

Uniprot Description

RAGE: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Interacts with S100B, S100A1 and APP. Interacts with S100A12. Endothelial cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Cell cycle regulation; Motility/polarity/chemotaxis; Membrane protein, integral

Cellular Component: extracellular space; cell surface; cell soma; membrane; axon; cytoplasm; integral to membrane; basal plasma membrane; plasma membrane; cytosol

Molecular Function: identical protein binding; protein binding; advanced glycation end-product receptor activity

Biological Process: positive regulation of JNK activity; positive regulation of apoptosis; positive regulation of smooth muscle cell proliferation; negative regulation of collagen biosynthetic process; negative regulation of cell adhesion; positive regulation of smooth muscle cell migration; JAK-STAT cascade; induction of positive chemotaxis; activation of NF-kappaB transcription factor; calcium ion homeostasis; positive regulation of fibroblast proliferation; negative regulation of protein amino acid phosphorylation; regulation of DNA binding; positive regulation of neuron apoptosis; negative regulation of endothelial cell proliferation; regulation of inflammatory response; response to hypoxia; positive regulation of protein amino acid phosphorylation; positive regulation of phagocytosis, engulfment; inflammatory response; neurite development; positive regulation of autophagy; positive regulation of inflammatory response; positive regulation of cell migration