Rabbit RDC1 Polyclonal Antibody | anti-RDC1 antibody

Polyclonal Antibody to RDC1

Cat. Num. AAA668765

• Gene Names: ACKR3; RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
• Reactivity: Human; Predicted: Mouse
• Applications: Western Blot
• Purity: Purified; Protein A Chromatography
• Synonyms: RDC1; Polyclonal Antibody; Polyclonal Antibody to RDC1; ACKR3; CMKOR1; CXCR7; GPR159; C-X-C chemokine receptor type 7; Chemokine orphan receptor 1; G-protein coupled receptor 159; RDC-1; G-protein coupled receptor RDC1 homolog; Antibody to RDC1; Anti-RDC1 Antibody; RDC1 Antibody; anti-RDC1 antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified; Protein A Chromatography
• Form/Format: 25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
• Sequence Length: 362

• Applicable Applications for anti-RDC1 antibody: Western Blot (WB)
• Application Notes: WB: 0.5-1 ug/ml
• Immunogen Information: A partial length recombinant RDC1 protein (amino acids 96-302) was used as the immunogen for this antibody.
• Antigen: RDC1
• Preparation and Storage: Store the antibody at 4 degree C, stable for 6 months.; For long-term storage, store at -20 degree C.; Avoid repeated freeze and thaw cycles.

Western Blot (WB)

(Fig-1: Western blot analysis RDC1. Anti-RDC1 antibody (11-8009) was used at 0.5 ug/ml on HL-60 lysate.)

Related Product Information for anti-RDC1 antibody

RDC1 is a chemokine receptor that belongs to the membrane-bound G protein-coupled receptor superfamily. It is frequently and specifically expressed in tumor-associated vessels. It controls cell proliferation and migration during development, tumorigenesis, and inflammatory processes. It represents an atypical or scavenger chemokine receptor which modulates the function of CXCR4. RDC1 is involved in the EMT (Epithelial-mesenchymal transition) process of epithelial ovarian carcinomas.

Product Categories/Family for anti-RDC1 antibody

Antibodies; Cell Signalling

NCBI and Uniprot Product Information

• NCBI GI #: 115502380
• NCBI GeneID: 57007
• UniProt Accession #: P25106; Q53RV4; Q8NE10; Q92938; Q92986; A8K6J4
• Molecular Weight: 41,493 Da
• NCBI Official Full Name: Atypical chemokine receptor 3
• NCBI Official Synonym Full Names: atypical chemokine receptor 3
• NCBI Official Symbol: ACKR3
• NCBI Official Synonym Symbols: RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
• NCBI Protein Information: atypical chemokine receptor 3
• UniProt Protein Name: Atypical chemokine receptor 3
• Protein Family: Non-reducing polyketide synthase
• UniProt Gene Name: ACKR3
• UniProt Synonym Gene Names: CMKOR1; CXCR7; GPR159; RDC1; CXC-R7; CXCR-7; RDC-1

NCBI Description

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]

Uniprot Description

CMKOR1: Receptor for chemokines CXCL12/SDF1 and CXCL11. Does not elicit classical chemokine receptor signaling; chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Acts as a scavenger for CXCL12/SDF1 and, to a lesser extent, for CXCL11. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cell surface; coated pit; endosome; intracellular membrane-bound organelle; plasma membrane

Molecular Function: C-X-C chemokine binding; C-X-C chemokine receptor activity; protein binding; scavenger receptor activity

Biological Process: receptor internalization