Rabbit RCAN2 Polyclonal Antibody | anti-Rcan2 antibody

RCAN2 Antibody

Cat. Num. AAA151578

• Gene Names: Rcan2; Csp2; MCIP2; ZAKI-4; Dscr1l1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: RCAN2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: RCAN2; Polyclonal Antibody; RCAN2 Antibody; Csp2; MCIP2; ZAKI-4; Dscr1l1; Zaki4; Calcipressin-2; Calcineurin inhibitory protein ZAKI-4; regulator of calcineurin 2; anti-Rcan2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: RCAN2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 197

• Applicable Applications for anti-Rcan2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: RCAN2 antibody can be used for detection of RCAN2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: RCAN2 antibody was raised against a 14 amino acid synthetic peptide near the center of human RCAN2.
• Buffer: RCAN2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: RCAN2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of RCAN2 in 3T3 cell lysate with RCAN2 antibody at (A) 1 and (B) 2 μg/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of RCAN2 in mouse brain tissue with RCAN2 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of RCAN2 in mouse brain tissue with RCAN2 antibody at 20 μg/mL.)

Related Product Information for anti-Rcan2 antibody

RCAN2 Antibody: Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.

NCBI and Uniprot Product Information

• NCBI GI #: 38328420
• NCBI GeneID: 53901
• UniProt Accession #: Q9JHG2; Q8VIP5
• Molecular Weight: 22,025 Da
• NCBI Official Full Name: Rcan2 protein
• NCBI Official Synonym Full Names: regulator of calcineurin 2
• NCBI Official Symbol: Rcan2
• NCBI Official Synonym Symbols: Csp2; MCIP2; ZAKI-4; Dscr1l1
• NCBI Protein Information: calcipressin-2; calcineurin inhibitory protein ZAKI-4; Down syndrome critical region gene 1-like 1; down syndrome candidate region 1-like protein 1; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2
• UniProt Protein Name: Calcipressin-2
• Protein Family: Calcipressin
• UniProt Gene Name: Rcan2
• UniProt Synonym Gene Names: Dscr1l1; Zaki4; MCIP2
• UniProt Entry Name: RCAN2_MOUSE

Uniprot Description

RCAN2: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: intracellular

Molecular Function: nucleotide binding

Biological Process: calcineurin-NFAT signaling pathway; short-term memory; calcium-mediated signaling; response to stress; response to oxidative stress; locomotion during locomotory behavior