Rabbit RBM8A Polyclonal Antibody | anti-RBM8A antibody

RBM8A Polyclonal Antibody

Cat. Num. AAA2562309

• Gene Names: RBM8A; TAR; Y14; RBM8; ZNRP; RBM8B; ZRNP1; BOV-1A; BOV-1B; BOV-1C; MDS014; DEL1q21.1; C1DELq21.1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: RBM8A; Polyclonal Antibody; RBM8A Polyclonal Antibody; Binder of OVCA1 1; Binder of OVCA1-1; BOV 1; BOV 1A; BOV 1B; BOV 1C; BOV-1; BOV1; BOV1A; BOV1B; BOV1C; HSPC 114; HSPC114; MDS 014; MDS014; RBM 8; RBM 8A; RBM 8B; RBM8; Rbm8a; RBM8B; Ribonucleoprotein RBM 8; Ribonucleoprotein RBM 8A; Ribonucleoprotein RBM8; Ribonucleoprotein RBM8A; RNA binding motif protein 8; RNA binding motif protein 8A; RNA binding motif protein 8B; RNA binding protein 8A; RNA binding protein Y14; RNA-binding motif protein 8A; RNA-binding protein 8A; RNA-binding protein Y14; ZNRP; ZRNP 1; ZRNP1; anti-RBM8A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.5mg/mL (varies by lot)
• Sequence Length: 174

• Applicable Applications for anti-RBM8A antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:25-1:100; ELISA: 1:5000-1:10000
• Immunogen: Full length fusion protein
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using RBM8A Polyclonal Antibody at dilution of 1:30(×200))

Related Product Information for anti-RBM8A antibody

This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome.

Product Categories/Family for anti-RBM8A antibody

Cancer; Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 4826972
• NCBI GeneID: 9939
• NCBI Accession #: NP_005096.1; BC017088
• NCBI GenBank Nucleotide #: NP_005096.1
• UniProt Accession #: Q9Y5S9
• NCBI Official Full Name: RNA-binding protein 8A
• NCBI Official Synonym Full Names: RNA binding motif protein 8A
• NCBI Official Symbol: RBM8A
• NCBI Official Synonym Symbols: TAR; Y14; RBM8; ZNRP; RBM8B; ZRNP1; BOV-1A; BOV-1B; BOV-1C; MDS014; DEL1q21.1; C1DELq21.1
• NCBI Protein Information: RNA-binding protein 8A
• UniProt Protein Name: RNA-binding protein 8A
• Protein Family: RNA-binding protein
• UniProt Gene Name: RBM8A
• UniProt Synonym Gene Names: RBM8; BOV-1
• UniProt Entry Name: RBM8A_HUMAN

NCBI Description

This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome. [provided by RefSeq, Jul 2013]

Uniprot Description

RBM8A: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Remains associated with mRNAs in the cytoplasm until the mRNAs engage the translation machinery. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. Complex with MAGOH is a component of the nonsense mediated decay (NMD) pathway. Belongs to the RBM8A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation; RNA splicing; Spliceosome; RNA-binding

Chromosomal Location of Human Ortholog: 1q21.1

Cellular Component: nucleoplasm; cytoplasm; nuclear speck; nucleus; cytosol

Molecular Function: mRNA binding; protein binding; RNA binding; nucleotide binding

Biological Process: transcription from RNA polymerase II promoter; regulation of translation; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; RNA splicing; mRNA catabolic process, nonsense-mediated decay; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription; regulation of alternative nuclear mRNA splicing, via spliceosome

Disease: Thrombocytopenia-absent Radius Syndrome