Rabbit anti-Human, Mouse RBM38 Polyclonal Antibody | anti-RBM38 antibody

RBM38 Antibody

Cat. Num. AAA9404857

• Gene Names: RBM38; RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: RBM38; Polyclonal Antibody; RBM38 Antibody; RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2; anti-RBM38 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total RBM38 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.3 mg/ml (varies by lot)
• Sequence Length: 271

• Applicable Applications for anti-RBM38 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:200-1:1000; Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human RNA binding motif protein 38
• Target Name: RBM38
• Preparation and Storage: Store at -20 degree C

Testing Data

(Gel: 10%SDS-PAGE Lysates (from left to right): Human heart tissue Amount of lysate: 40ug per lane Primary antibody: 1/200 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/35.)

Related Product Information for anti-RBM38 antibody

RBM38 (RNA-binding protein 38), also known as RNPC1 or SEB4. RBM38 is a cell cycle protein found in the cytosol and the Nucleus that exists as two alternatively spliced isoforms, 1 (RNPC1a) and 2 (RNPC1b), of 239 and 121 amino acids, respectively. Independent of p53 expression, RBM38 isoform 1 induces cell cycle arrest in G1 phase through maintaining transcript stability at the 3¡¯-UTR of p21, a regulator of cell cycle progression at S phase. RBM38 is also an mRNA splicing factor that regulates the expression of FGFR2. RBM38 contains one RRM (RNA recognition motif) domain.

Product Categories/Family for anti-RBM38 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 619534169
• NCBI GeneID: 55544
• NCBI Accession #: NP_001278709.1
• NCBI GenBank Nucleotide #: NM_001291780.1
• UniProt Accession #: Q9H0Z9; Q15350; Q15351; Q9BYK3; Q9BYK4; A6NDK1; A6NMU6
• Molecular Weight: 12,914 Da
• NCBI Official Full Name: RNA-binding protein 38 isoform c
• NCBI Official Synonym Full Names: RNA binding motif protein 38
• NCBI Official Symbol: RBM38
• NCBI Official Synonym Symbols: RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2
• NCBI Protein Information: RNA-binding protein 38
• UniProt Protein Name: RNA-binding protein 38
• Protein Family: RNA-binding protein
• UniProt Gene Name: RBM38
• UniProt Synonym Gene Names: RNPC1; SEB4
• UniProt Entry Name: RBM38_HUMAN

Uniprot Description

RBM38: RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. Belongs to the RBM38 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: nucleoplasm; cytosol; nucleus

Molecular Function: mRNA binding; mRNA 3'-UTR binding; nucleotide binding

Biological Process: negative regulation of cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of RNA splicing; RNA splicing; cell cycle; cell cycle arrest; cell differentiation; mRNA processing; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest