Rabbit anti-Human RBM38 Polyclonal Antibody | anti-RBM38 antibody

RBM38 Antibody

Cat. Num. AAA7053289

• Gene Names: RBM38; RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Immunofluorescence
• Purity: >95%, Protein G purified
• Synonyms: RBM38; Polyclonal Antibody; RBM38 Antibody; RNA-binding protein 38; CLL-associated antigen KW-5; HSRNASEB; RNA-binding motif protein 38; RNA-binding region-containing protein 1; ssDNA-binding protein SEB4; RNPC1; SEB4; anti-RBM38 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 271

• Applicable Applications for anti-RBM38 antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: IHC: 1:20-1:200; IF: 1:50-1:200
• Immunogen: Recombinant Human RNA-binding protein 38 protein (1-239AA)
• Conjugation: Non-conjugated
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain tissue using MBS7053289 at dilution of 1:100)

Immunofluorescence (IF)

(Immunofluorescent analysis of A549 cells using MBS7053289 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))

Related Product Information for anti-RBM38 antibody

RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.

NCBI and Uniprot Product Information

• NCBI GI #: 619534169
• NCBI GeneID: 55544
• NCBI Accession #: NP_001278709.1
• NCBI GenBank Nucleotide #: NM_001291780.1
• UniProt Accession #: Q9H0Z9; Q15350; Q15351; Q9BYK3; Q9BYK4; A6NDK1; A6NMU6
• Molecular Weight: 12,914 Da
• NCBI Official Full Name: RNA-binding protein 38 isoform c
• NCBI Official Synonym Full Names: RNA binding motif protein 38
• NCBI Official Symbol: RBM38
• NCBI Official Synonym Symbols: RNPC1; SEB4B; SEB4D; HSRNASEB; dJ800J21.2
• NCBI Protein Information: RNA-binding protein 38
• UniProt Protein Name: RNA-binding protein 38
• Protein Family: RNA-binding protein
• UniProt Gene Name: RBM38
• UniProt Synonym Gene Names: RNPC1; SEB4

Uniprot Description

RBM38: RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. Belongs to the RBM38 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 20q13.31

Biological Process: regulation of RNA splicing