Rabbit RBM28 Polyclonal Antibody | anti-RBM28 antibody

RBM28 Rabbit Polyclonal

Cat. Num. AAA7603406

• Gene Names: RBM28; ANES
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RBM28; Polyclonal Antibody; RBM28 Rabbit Polyclonal; anti-RBM28 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 759

• Applicable Applications for anti-RBM28 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: RNA binding motif protein 28
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(NIH/3T3 cells were subjected to SDS PAGE followed by western blot with MBS7603406 (RBM28 antibody) at dilution of 1:1500)

NCBI and Uniprot Product Information

• NCBI GI #: 187960109
• NCBI GeneID: 55131
• NCBI Accession #: NP_060547.2
• NCBI GenBank Nucleotide #: NM_018077.2
• Molecular Weight: 69,923 Da
• NCBI Official Full Name: RNA-binding protein 28 isoform 1
• NCBI Official Synonym Full Names: RNA binding motif protein 28
• NCBI Official Symbol: RBM28
• NCBI Official Synonym Symbols: ANES
• NCBI Protein Information: RNA-binding protein 28
• UniProt Protein Name: RNA-binding protein 28
• Protein Family: RNA-binding protein
• UniProt Gene Name: RBM28
• UniProt Entry Name: RBM28_HUMAN

NCBI Description

The protein encoded by this gene is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein (snRNP)complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Description

RBM28: Nucleolar component of the spliceosomal ribonucleoprotein complexes. Defects in RBM28 are the cause of alopecia neurologic defects and endocrinopathy syndrome (ANES). Affected individuals have hair loss of variable severity, ranging from complete alopecia to near-normal scalp hair with absence of body hair. All have moderate to severe mental retardation, progressive motor deterioration and central hypogonadotropic hypogonadism with delayed or absent puberty and central adrenal insufficiency. Additional features included short stature, microcephaly, gynecomastia, pigmentary anomalies, hypodontia, kyphoscoliosis, ulnar deviation of the hands, and loss of subcutaneous fat.

Protein type: Nucleolus; RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 7q32.1

Cellular Component: nucleolus; spliceosome

Molecular Function: nucleotide binding

Biological Process: mRNA processing; RNA splicing

Disease: Alopecia, Neurologic Defects, And Endocrinopathy Syndrome