Rabbit anti-Human RBM17 Polyclonal Antibody | anti-RBM17 antibody

RBM17 Antibody

Cat. Num. AAA7043716

• Gene Names: RBM17; SPF45
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: RBM17; Polyclonal Antibody; RBM17 Antibody; Splicing factor 45; 45 kDa-splicing factor; RNA-binding motif protein 17; SPF45; anti-RBM17 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 401

• Applicable Applications for anti-RBM17 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC: 1:20-1:200
• Species: Human
• Immunogen: Recombinant human Splicing factor 45 protein (N-240AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-163281 / sc-163283
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon cancer using MBS7043716 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human ovarian cancer using MBS7043716 at dilution of 1:100)

Related Product Information for anti-RBM17 antibody

Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.

NCBI and Uniprot Product Information

• NCBI GI #: 224549005
• NCBI GeneID: 84991
• NCBI Accession #: NP_001139019.1
• NCBI GenBank Nucleotide #: NM_001145547.1
• UniProt Accession #: Q96I25; Q96GY6
• Molecular Weight: 44,962 Da
• NCBI Official Full Name: splicing factor 45
• NCBI Official Synonym Full Names: RNA binding motif protein 17
• NCBI Official Symbol: RBM17
• NCBI Official Synonym Symbols: SPF45
• NCBI Protein Information: splicing factor 45
• UniProt Protein Name: Splicing factor 45
• Protein Family: Splicing factor
• UniProt Gene Name: RBM17
• UniProt Synonym Gene Names: SPF45
• UniProt Entry Name: SPF45_HUMAN

NCBI Description

This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. [provided by RefSeq, Mar 2009]

Uniprot Description

RBM17: Splice factor that binds to the single stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.

Protein type: Spliceosome; RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 10p15.1

Molecular Function: protein binding

Biological Process: alternative nuclear mRNA splicing, via spliceosome