Rabbit RBM10 Polyclonal Antibody | anti-RBM10 antibody

RBM10 Antibody (N-term)

Cat. Num. AAA9214220

• Gene Names: RBM10; S1-1; TARPS; GPATC9; ZRANB5; GPATCH9; DXS8237E
• Reactivity: Human (Predicted Reactivity: Mouse)
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: RBM10; Polyclonal Antibody; RBM10 Antibody (N-term); RNA-binding protein 10; G patch domain-containing protein 9; RNA-binding motif protein 10; RNA-binding protein S1-1; S1-1; DXS8237E; GPATC9; GPATCH9; KIAA0122; anti-RBM10 antibody

• Host: Rabbit
• Reactivity: Human (Predicted Reactivity: Mouse)
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This RBM10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-113 amino acids from the N-terminal region of human RBM10.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.5 (varies by lot)
• Sequence Positions: 85-113
• Sequence Length: 852

• Applicable Applications for anti-RBM10 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(RBM10 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RBM10 antibody detected the RBM10 protein (arrow).)

Related Product Information for anti-RBM10 antibody

The protein encoded by this gene contains RNA recognition
motif found in a variety of RNA binding proteins, including various
hnRNP proteins, proteins implicated in regulation of alternative
splicing, and protein components of snRNPs. In vitro studies showed
that the rat homolog bound to RNA homopolymers, with a preference
for G and U polyribonucleotides. This gene is part of a gene
cluster on chromosome Xp11.23, and its 3' end lies within 20 kb
upstream of UBE1. Two transcript variants encoding different
isoforms have been identified for this gene.

References

Johnston, J.J., et al. Am. J. Hum. Genet. 86(5):743-748(2010)
Inoue, A., et al. Biol. Cell 100(9):523-535(2008)
Dephoure, N., et al. Proc. Natl. Acad. Sci. U.S.A. 105(31):10762-10767(2008)
Martin-Garabato, E., et al. Cancer Genomics Proteomics 5 (3-4), 169-173 (2008) :
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)

NCBI and Uniprot Product Information

• NCBI GI #: 325120982
• NCBI GeneID: 8241
• NCBI Accession #: NP_001191395.1; NP_001191396.1; NP_005667.2; NP_690595.1
• NCBI GenBank Nucleotide #: NM_001204466.1
• UniProt Accession #: P98175; Q14136; Q5JRR2; Q9BTE4; Q9BTX0; Q9NTB1; C4AM81
• Molecular Weight: 103533
• NCBI Official Full Name: RNA-binding protein 10 isoform 3
• NCBI Official Synonym Full Names: RNA binding motif protein 10
• NCBI Official Symbol: RBM10
• NCBI Official Synonym Symbols: S1-1; TARPS; GPATC9; ZRANB5; GPATCH9; DXS8237E
• NCBI Protein Information: RNA-binding protein 10
• UniProt Protein Name: RNA-binding protein 10
• Protein Family: RNA-binding protein
• UniProt Gene Name: RBM10
• UniProt Synonym Gene Names: DXS8237E; GPATC9; GPATCH9; KIAA0122; S1-1
• UniProt Entry Name: RBM10_HUMAN

NCBI Description

This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]

Uniprot Description

May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) ().