Rabbit anti-Mouse RBFOX3 Polyclonal Antibody | anti-RBFOX3 antibody

Anti-RBFOX3 Antibody, Rabbit Polyclonal

Cat. Num. AAA8103360

• Gene Names: Rbfox3; NeuN; Fox-3; Hrnbp3; Neuna60
• Reactivity: Mouse
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: RBFOX3; Polyclonal Antibody; Anti-RBFOX3 Antibody; Rabbit Polyclonal; RBFOX3 Antibody; Rabbit PAb; Antigen Affinity Purified; RNA binding protein; fox-1 homolog (C. elegans) 3; Anti-Fox-3 Antibody; Anti-Hrnbp3 Antibody; Anti-NeuN Antibody; Anti-Neuna60 Antibody; anti-RBFOX3 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse RBFOX3
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-RBFOX3 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the center region of the Mouse RBFOX3
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse RBFOX3, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of mouse RBFOX3 in mouse brain with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)

Immunohistochemistry (IHC)

(Immunochemical staining of mouse RBFOX3 in mouse cerebellum with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-RBFOX3 antibody

RBFOX3, an RNA-binding fox protein, plays an important role in the differentiation of neuronal development. Targeting RBFOX3 may improve the inhibition of HCC growth and progression by 5-FU, and provide a novel potential therapeutic strategy for HCC. RBFOX3/NeuN is a neuronal splicing regulator involved in neural circuitry balance, as well as neurogenesis and synaptogenesis. Rbfox3 is expressed in neurons; however, in the retina, expression is restricted to cells in the ganglion cell layer and some cells of the inner nuclear layer. Rbfox3 is expressed in a layer-specific manner in the retina. The deletion of Rbfox3 resulted in a reduction in the thickness of the inner plexiform layer of the retina, where synapses are formed.

NCBI and Uniprot Product Information

• NCBI GI #: 85677499
• NCBI GeneID: 52897
• NCBI Accession #: NP_001020102
• NCBI GenBank Nucleotide #: NM_001024931.2
• UniProt Accession #: Q8BIF2; Q3TUE0; Q7TQI4; A2A4W7; A2A4W8; B7ZC12; B7ZC13; D1GI07
• NCBI Official Full Name: RNA binding protein fox-1 homolog 3 isoform 3
• NCBI Official Synonym Full Names: RNA binding protein, fox-1 homolog (C. elegans) 3
• NCBI Official Symbol: Rbfox3
• NCBI Official Synonym Symbols: NeuN; Fox-3; Hrnbp3; Neuna60
• NCBI Protein Information: RNA binding protein fox-1 homolog 3
• UniProt Protein Name: RNA binding protein fox-1 homolog 3
• Protein Family: RNA binding protein
• UniProt Gene Name: Rbfox3
• UniProt Synonym Gene Names: D11Bwg0517e; Hrnbp3; Fox-3; NeuN
• UniProt Entry Name: RFOX3_MOUSE

Uniprot Description

NeuN: RNA-binding protein that regulates alternative splicing events.

Protein type: RNA processing; DNA-binding; RNA splicing

Cellular Component: cell soma; cytoplasm; perikaryon; intracellular; nucleus

Molecular Function: protein binding; DNA binding; nucleic acid binding; RNA binding; nucleotide binding

Biological Process: regulation of RNA splicing; RNA splicing; mRNA processing; regulation of alternative nuclear mRNA splicing, via spliceosome