Rabbit anti-Mouse RASAL1 Polyclonal Antibody | anti-RASAL1 antibody

RASAL1, ID (RASAL1, RASAL, RasGAP-activating-like protein 1)

Cat. Num. AAA6001809

• Gene Names: RASAL1; RASAL
• Reactivity: Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: RASAL1; Polyclonal Antibody; ID (RASAL1; RASAL; RasGAP-activating-like protein 1); Anti -RASAL1; anti-RASAL1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-RASAL1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: RASAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 amino acids from the Central region of human RASAL1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(RASAL1 Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the RASAL1 antibody detected the RASAL1 protein (arrow).)

Related Product Information for anti-RASAL1 antibody

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described

Product Categories/Family for anti-RASAL1 antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 302058252
• NCBI GeneID: 8437
• NCBI Accession #: NP_001180449.1
• NCBI GenBank Nucleotide #: NM_001193520.1
• UniProt Accession #: O95294; Q52M03; Q59H24; Q96CC7; B7ZKM4; C9JFK5; F8VQX1
• Molecular Weight: 90,016 Da
• NCBI Official Full Name: rasGAP-activating-like protein 1 isoform 1
• NCBI Official Synonym Full Names: RAS protein activator like 1 (GAP1 like)
• NCBI Official Symbol: RASAL1
• NCBI Official Synonym Symbols: RASAL
• NCBI Protein Information: rasGAP-activating-like protein 1; GAP1 like protein
• UniProt Protein Name: RasGAP-activating-like protein 1
• Protein Family: RasGAP-activating-like protein
• UniProt Gene Name: RASAL1
• UniProt Synonym Gene Names: RASAL
• UniProt Entry Name: RASL1_HUMAN

NCBI Description

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

Uniprot Description

RASAL1: a GTPase activating protein for Ras. Negatively regulates Ras (H-Ras) signaling activity. Two alternatively-spliced isoforms have been described. PITX1 inhibits tumorigenicity of the Ras pathway by inducing the transcription of RASAL1, which in turn inactivates Ras. Two alternatively-spliced isoforms have been described.

Protein type: GAPs, Ras; GAPs

Chromosomal Location of Human Ortholog: 12q23-q24

Cellular Component: cytoplasm; plasma membrane; cytosol

Molecular Function: metal ion binding; phospholipid binding

Biological Process: negative regulation of Ras protein signal transduction; signal transduction