Rabbit anti-Human RAP1 Polyclonal Antibody | anti-RAP1 antibody

RAP1 Conjugated Antibody

Cat. Num. AAA9453333

• Gene Names: TERF2IP; RAP1; DRIP5
• Reactivity: Human
• Applications: Most Applications
• Synonyms: RAP1; Polyclonal Antibody; RAP1 Conjugated Antibody; TERF2IP; DRIP5; HRap1; RAP1 homolog; anti-RAP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: RAP1 antibody detects endogenous levels of total RAP1
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-RAP1 antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: A synthesized peptide derived from human RAP1
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

NCBI and Uniprot Product Information

• NCBI GI #: 119616024
• NCBI GeneID: 54386
• UniProt Accession #: Q9NYB0; Q4W4Y2; Q8WYZ3; Q9NWR2; B4DQN4
• Molecular Weight: 44,260 Da
• NCBI Official Full Name: telomeric repeat binding factor 2, interacting protein, isoform CRA_a
• NCBI Official Synonym Full Names: telomeric repeat binding factor 2, interacting protein
• NCBI Official Symbol: TERF2IP
• NCBI Official Synonym Symbols: RAP1; DRIP5
• NCBI Protein Information: telomeric repeat-binding factor 2-interacting protein 1; hRap1; RAP1 homolog; TRF2-interacting telomeric protein 1; TERF2-interacting telomeric protein 1; repressor/activator protein 1 homolog; TRF2-interacting telomeric RAP1 protein; dopamine receptor in
• UniProt Protein Name: Telomeric repeat-binding factor 2-interacting protein 1
• Protein Family: Rap1 GTPase-activating protein
• UniProt Gene Name: TERF2IP
• UniProt Synonym Gene Names: DRIP5; RAP1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; RAP1 homolog; hRap1
• UniProt Entry Name: TE2IP_HUMAN

NCBI Description

The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]

Uniprot Description

TERF2IP: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. Associates with the I-kappa-B-kinase (IKK) core complex, composed of CHUK, IKBKB and IKBKG. Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with TERF2; the interaction is direct. Does not interact with TERF1. Interacts with SLX4/BTBD12. Ubiquitous. Highly expressed. Belongs to the RAP1 family.

Protein type: DNA replication

Chromosomal Location of Human Ortholog: 16q23.1

Cellular Component: nucleoplasm; nuclear chromosome; chromosome, telomeric region; nuclear telomere cap complex; Mre11 complex; nuclear chromosome, telomeric region; cytoplasm; nuclear envelope; nucleus

Molecular Function: protein binding; telomeric DNA binding

Biological Process: negative regulation of telomere maintenance; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of DNA recombination at telomere; telomere maintenance via telomerase; positive regulation of peptidyl-serine phosphorylation; telomere maintenance; activation of NF-kappaB transcription factor; protection from non-homologous end joining at telomere