Rabbit anti-Human, Mouse RANBP17 Polyclonal Antibody | anti-RANBP17 antibody

RANBP17, NT (RANBP17, Ran-binding protein 17) (Azide free) (HRP)

Cat. Num. AAA6340200

• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: RANBP17; Polyclonal Antibody; NT (RANBP17; Ran-binding protein 17) (Azide free) (HRP); Ran-binding protein 17; anti-RANBP17 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-RANBP17 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: RANBP17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 148-175 amino acids from the N-terminal region of human RANBP17.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(RANBP17 Antibody (N-term) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the RANBP17 antibody detected the RANBP17 protein (arrow).)

Related Product Information for anti-RANBP17 antibody

The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.

Product Categories/Family for anti-RANBP17 antibody

Antibodies; Binding Proteins

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Kutay, U., et al. J. Biol. Chem. 275(51):40163-40168(2000). Koch, P., et al. Biochem. Biophys. Res. Commun. 278(1):241-249(2000).

NCBI and Uniprot Product Information

• NCBI GI #: 12597633
• NCBI GeneID: 64901
• NCBI Accession #: NP_075048.1
• NCBI GenBank Nucleotide #: NM_022897.3
• UniProt Accession #: Q9H2T7
• Molecular Weight: 124,375 Da
• NCBI Official Full Name: ran-binding protein 17
• NCBI Official Synonym Full Names: RAN binding protein 17
• NCBI Official Symbol: RANBP17
• NCBI Protein Information: ran-binding protein 17
• UniProt Protein Name: Ran-binding protein 17
• Protein Family: Ran-binding protein
• UniProt Gene Name: RANBP17
• UniProt Entry Name: RBP17_HUMAN

NCBI Description

The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

Uniprot Description

RANBP17: May function as a nuclear transport receptor. Belongs to the exportin family.

Protein type: Nuclear import; Nuclear export

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: cytoplasm; nuclear pore

Molecular Function: GTP binding; Ran GTPase binding

Biological Process: mRNA transport; protein import into nucleus