Rabbit XPO7 Polyclonal Antibody | anti-XPO7 antibody

XPO7 Polyclonal Antibody

Cat. Num. AAA9432859

• Gene Names: XPO7; EXP7; RANBP16
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity purification
• Synonyms: XPO7; Polyclonal Antibody; XPO7 Polyclonal Antibody; EXP7; RANBP16; exportin-7; anti-XPO7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 50% glycerol, pH7.4

• Applicable Applications for anti-XPO7 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthetic synthetic peptide of human XPO7 (NP_055839.3).
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using XPO7 antibody.)

Related Product Information for anti-XPO7 antibody

The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.

Product Categories/Family for anti-XPO7 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 154448892
• NCBI GeneID: 23039
• NCBI Accession #: NP_055839.3
• NCBI GenBank Nucleotide #: NM_015024.4
• UniProt Accession #: Q9UIA9; O94846; Q6PJK9; Q8NEK7
• Molecular Weight: 123,907 Da
• NCBI Official Full Name: exportin-7
• NCBI Official Synonym Full Names: exportin 7
• NCBI Official Symbol: XPO7
• NCBI Official Synonym Symbols: EXP7; RANBP16
• NCBI Protein Information: exportin-7; RAN binding protein 16
• UniProt Protein Name: Exportin-7
• Protein Family: Exportin
• UniProt Gene Name: XPO7
• UniProt Synonym Gene Names: KIAA0745; RANBP16; Exp7
• UniProt Entry Name: XPO7_HUMAN

NCBI Description

The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

Uniprot Description

Exportin-7: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the exportin family.

Protein type: Nuclear export; Nuclear import; Karyopherin

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: cytoplasm; nuclear pore; nucleus

Molecular Function: nuclear export signal receptor activity; Ran GTPase binding

Biological Process: mRNA transport; protein export from nucleus