Rabbit anti-Human RAMP3 Polyclonal Antibody | anti-RAMP3 antibody

RAMP3 antibody

Cat. Num. AAA9410648

• Reactivity: Human
• Applications: Western Blot, Immunofluorescence
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: RAMP3; Polyclonal Antibody; RAMP3 antibody; anti-RAMP3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total RAMP3 antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 148

• Applicable Applications for anti-RAMP3 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunofluorescence: 1:50 - 1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human RAMP3.
• Target Name: RAMP3
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using RAMP3 antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of MCF-7 cell using RAMP3 antibody. Blue: DAPI for nuclear staining.)

Related Product Information for anti-RAMP3 antibody

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.

Product Categories/Family for anti-RAMP3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 5032023
• NCBI GeneID: 10268
• NCBI Accession #: NP_005847.1
• NCBI GenBank Nucleotide #: NM_005856.2
• UniProt Accession #: O60896; Q7Z2Y1
• Molecular Weight: 16,518 Da
• NCBI Official Full Name: receptor activity-modifying protein 3
• NCBI Official Synonym Full Names: receptor (G protein-coupled) activity modifying protein 3
• NCBI Official Symbol: RAMP3
• NCBI Protein Information: receptor activity-modifying protein 3
• UniProt Protein Name: Receptor activity-modifying protein 3
• Protein Family: Receptor activity-modifying protein
• UniProt Gene Name: RAMP3
• UniProt Synonym Gene Names: CRLR activity-modifying protein 3
• UniProt Entry Name: RAMP3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

RAMP3: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Belongs to the RAMP family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7p13-p12

Cellular Component: cell surface; integral to plasma membrane; lysosome; plasma membrane; intracellular; receptor complex

Molecular Function: protein binding; coreceptor activity; receptor activity; protein transporter activity

Biological Process: intracellular protein transport; protein transport; receptor internalization; calcium ion transport; negative regulation of transcription, DNA-dependent; positive regulation of receptor recycling; regulation of G-protein coupled receptor protein signaling pathway