Rabbit RAD54L Polyclonal Antibody | anti-RAD54L antibody
RAD54L (DNA Replication, Repair and Recombination Factor)
Purified by affinity chromatography.
Purified by affinity chromatography.
Dilution: Immunohistochemistry (Frozen): 1:200-1:1000
Immunocytochemistry: 1:200-1:1000
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.
Uniprot Description
RAD54L: Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments. May play also an essential role in telomere length maintenance and telomere capping in mammalian cells. Belongs to the SNF2/RAD54 helicase family.
Protein type: Helicase; EC 3.6.4.-; EC 3.6.1.-; Cell cycle regulation; DNA repair, damage
Chromosomal Location of Human Ortholog: 1p32
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; DNA binding; helicase activity; ATP binding
Biological Process: response to drug; meiosis; DNA strand renaturation; response to ionizing radiation; DNA repair; chromosome organization and biogenesis; double-strand break repair via homologous recombination; DNA recombination
Disease: Lymphoma, Non-hodgkin, Familial; Breast Cancer
Research Articles on RAD54L
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Product Notes
The RAD54L rad54l (Catalog #AAA612064) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RAD54L (DNA Replication, Repair and Recombination Factor) reacts with Human, Rodent and may cross-react with other species as described in the data sheet. AAA Biotech's RAD54L can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunohistochemistry (IHC), Immunocytochemistry (ICC). Suitable for use in ELISA, Immunohistochemistry and Immunocytochemistry. Dilution: Immunohistochemistry (Frozen): 1:200-1:1000 Immunocytochemistry: 1:200-1:1000. Researchers should empirically determine the suitability of the RAD54L rad54l for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAD54L, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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