Rabbit anti-Human RAB3GAP2 Polyclonal Antibody | anti-RAB3GAP2 antibody

RAB3GAP2 Polyclonal Antibody

Cat. Num. AAA3007673

• Gene Names: RAB3GAP2; p150; SPG69; WARBM2; RAB3GAP150; RAB3-GAP150
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: RAB3GAP2; Polyclonal Antibody; RAB3GAP2 Polyclonal Antibody; Rab3 GTPase-activating protein non-catalytic subunit; •RGAP-iso; •Rab3 GTPase-activating protein 150 kDa subunit; Rab3-GAP p150; Rab3-GAP150; Rab3-GAP regulatory subunit; anti-RAB3GAP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: RAB3GAP2 pAb detects endogenous levels of RAB3GAP2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1393

• Applicable Applications for anti-RAB3GAP2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 400-450 of Human RAB3GAP2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of RAB3GAP2 pAb at 1:500 dilutionLane1:MCF-7 whole cell lysate (40ug) Lane2:SGC7901 whole cell lysate (40ug) Lane3:A549 whole cell lysate (40ug))

Related Product Information for anti-RAB3GAP2 antibody

Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.

NCBI and Uniprot Product Information

• NCBI GI #: 19923790
• NCBI GeneID: 25782
• NCBI Accession #: NP_036546.2
• NCBI GenBank Nucleotide #: NP_036546.2
• UniProt Accession #: Q9H2M9
• Molecular Weight: ~ 156kDa
• NCBI Official Full Name: rab3 GTPase-activating protein non-catalytic subunit
• NCBI Official Synonym Full Names: RAB3 GTPase activating non-catalytic protein subunit 2
• NCBI Official Symbol: RAB3GAP2
• NCBI Official Synonym Symbols: p150; SPG69; WARBM2; RAB3GAP150; RAB3-GAP150
• NCBI Protein Information: rab3 GTPase-activating protein non-catalytic subunit
• UniProt Protein Name: Rab3 GTPase-activating protein non-catalytic subunit
• Protein Family: Rab3 GTPase-activating protein
• UniProt Gene Name: RAB3GAP2
• UniProt Synonym Gene Names: KIAA0839; Rab3-GAP150
• UniProt Entry Name: RBGPR_HUMAN

NCBI Description

The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome.[provided by RefSeq, Oct 2009]

Uniprot Description

RAB3GAP2: Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters. Defects in RAB3GAP2 are the cause of Martsolf syndrome (MARTS). Martsolf syndrome is characterized by congenital cataracts, mental retardation, and hypogonadism. Inheritance is autosomal recessive. Defects in RAB3GAP2 are the cause of Warburg micro syndrome type 2 (WARBM2). WARBM2 is a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. Belongs to the Rab3-GAP regulatory subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rab; GAPs

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: protein complex; cytoplasm; plasma membrane

Molecular Function: protein heterodimerization activity; enzyme activator activity; Rab guanyl-nucleotide exchange factor activity; Rab GTPase binding; enzyme regulator activity; GTPase activator activity

Biological Process: positive regulation of catalytic activity; intracellular protein transport; regulation of GTPase activity; positive regulation of GTPase activity

Disease: Martsolf Syndrome; Warburg Micro Syndrome 2