Rabbit anti-Human RAB24 Polyclonal Antibody | anti-RAB24 antibody

RAB24 (S108) (Ras-related protein Rab-24, RAB24) (MaxLight 750)

Cat. Num. AAA6339633

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: RAB24; Polyclonal Antibody; RAB24 (S108) (Ras-related protein Rab-24; RAB24) (MaxLight 750); Ras-related protein Rab-24; anti-RAB24 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

• Applicable Applications for anti-RAB24 antibody: Immunohistochemistry (IHC), FLISA
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: RAB24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93~123 amino acids surrounding S108 of human RAB24.
• Conjugate: MaxLight750
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-RAB24 antibody

The GTPase Rab24 is thought to be involved in the regulation of vesicular transport associated with autophagy. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole).

Product Categories/Family for anti-RAB24 antibody

Antibodies; GTPase; Rab; Ras; Rho Proteins

References

Baehrecke EH. Nat Rev Mol Cell Biol. 6(6):505-10. (2005). Lum JJ, et al. Nat Rev Mol Cell Biol. 6(6):439-48. (2005). Greenberg JT. Dev Cell. 8(6):799-801. (2005). Levine B. Cell. 120(2):159-62. (2005). Shintani T and Klionsky DJ. Science. 306(5698):990-5. (2004).

NCBI and Uniprot Product Information

• NCBI GI #: 72534833
• NCBI GeneID: 53917
• NCBI Accession #: NP_001026847.1
• NCBI GenBank Nucleotide #: NM_001031677.3
• UniProt Accession #: Q969Q5; Q7Z4Z7
• Molecular Weight: 23,124 Da
• NCBI Official Full Name: ras-related protein Rab-24
• NCBI Official Synonym Full Names: RAB24, member RAS oncogene family
• NCBI Official Symbol: RAB24
• NCBI Protein Information: ras-related protein Rab-24
• UniProt Protein Name: Ras-related protein Rab-24
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB24
• UniProt Entry Name: RAB24_HUMAN

NCBI Description

RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]

Uniprot Description

RAB24: a small G protein of the Rab family. Differs from other Rab proteins in that it has a low intrinsic GTPase activity. May be involved in autophagy-related processes.

Protein type: Autophagy; G protein, monomeric; G protein; G protein, monomeric, Rab

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: mitochondrion; membrane; endocytic vesicle; autophagic vacuole; cytosol; endosome

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding

Biological Process: intracellular protein transport; autophagy; Rab protein signal transduction