Rabbit anti-Human QKI Polyclonal Antibody | anti-QKI antibody

QKI, NT (Protein Quaking, HqkI, Hqk, HKQ) (MaxLight 550)

Cat. Num. AAA6496327

• Gene Names: QKI; QK; Hqk; QK1; QK3; hqkI
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Immunoaffinity chromatography.
• Synonyms: QKI; Polyclonal Antibody; NT (Protein Quaking; HqkI; Hqk; HKQ) (MaxLight 550); anti-QKI antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human QKI.
• Purity/Purification: Purified by Immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
• Sequence Length: 325

• Applicable Applications for anti-QKI antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-1:50; FLISA: 1:1,000; WB: 1:50-1:100; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the N-terminal region of human QKI (KLH).
• Conjugate: MaxLight550
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-QKI antibody

Antibodies; RNA Processing

References

1. Zhao, L., J. Neurosci. 26(44), 11278-11286 (2006). 2. Haroutunian, V., Am J Psychiatry 163(10), 1834-1837 (2006). 3. Aberg, K., Proc. Natl. Acad. Sci. USA 103(19), 7482-7487 (2006).

NCBI and Uniprot Product Information

• NCBI GI #: 45827710
• NCBI GeneID: 9444
• NCBI Accession #: NP_996736
• NCBI GenBank Nucleotide #: NP_996736.1
• UniProt Accession #: Q96PU8
• Molecular Weight: 37.671
• NCBI Official Full Name: protein quaking isoform 3
• NCBI Official Synonym Full Names: QKI, KH domain containing RNA binding
• NCBI Official Symbol: QKI
• NCBI Official Synonym Symbols: QK; Hqk; QK1; QK3; hqkI
• NCBI Protein Information: protein quaking
• UniProt Protein Name: Protein quaking
• Protein Family: Protein quaking
• UniProt Gene Name: QKI
• UniProt Synonym Gene Names: HKQ; Hqk; HqkI
• UniProt Entry Name: QKI_HUMAN

NCBI Description

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Description

QKI: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor. 6 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: cytoplasm; nucleus

Molecular Function: mRNA binding; protein binding; SH3 domain binding

Biological Process: myelination; regulation of translation; muscle cell differentiation; mRNA transport; RNA splicing; long-chain fatty acid biosynthetic process; mRNA processing; vasculogenesis; spermatid development