Western Blot (WB)
(PUS10 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PUS10 antibody detected the PUS10 protein (arrow).)
Rabbit anti-Human PUS10 Polyclonal Antibody | anti-PUS10 antibody
PUS10 Antibody (N-term)
Western Blot (WB)
(PUS10 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PUS10 antibody detected the PUS10 protein (arrow).)
Western Blot (WB)
(PUS10 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PUS10 antibody detected the PUS10 protein (arrow).)
pseudouridine, is the most common posttranscriptional nucleotide
modification found in RNA and is essential for biologic functions
such as spliceosome biogenesis. Pseudouridylate synthases, such as
PUS10, catalyze pseudouridination of structural RNAs, including
transfer, ribosomal, and splicing RNAs. These enzymes also act as
RNA chaperones, facilitating the correct folding and assembly of
tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by
OMIM].
McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Park, S.Y., et al. BMB Rep 42(8):511-515(2009)
NCBI and Uniprot Product Information
NCBI Description
Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by OMIM, May 2009]
Uniprot Description
PUS10: Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death. Belongs to the pseudouridine synthase Pus10 family.
Protein type: Isomerase; RNA processing; EC 5.4.99.-
Chromosomal Location of Human Ortholog: 2p16.1
Molecular Function: RNA binding; pseudouridine synthase activity
Biological Process: pseudouridine synthesis; tRNA processing
Research Articles on PUS10
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Product Notes
The PUS10 pus10 (Catalog #AAA9212158) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 52-78. The PUS10 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PUS10 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PUS10 pus10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PUS10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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