Rabbit PTPRM / PTP Mu Polyclonal Antibody | anti-PTPRM antibody

Rabbit Polyclonal to Human PTPRM / PTP Mu

Cat. Num. AAA244815

• Gene Names: PTPRM; RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU
• Reactivity: Bat, Gibbon, Bovine, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat; Predicted Reactivity: Chicken (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: PTPRM / PTP Mu; Polyclonal Antibody; Rabbit Polyclonal to Human PTPRM / PTP Mu; Anti-PTPRM / PTP Mu Antibody (Internal) IHC-plus; PTPRM; HR-PTPu; PTP mu; PTPRL1; RPTPM; Ptpmu; R-PTP-MU; RPTPU; Human PTPRM; PTP Mu; anti-PTPRM antibody

• Host: Rabbit
• Reactivity: Bat, Gibbon, Bovine, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat; Predicted Reactivity: Chicken (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human PTPRM. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTPRK (50%), PTPRT (50%).
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1452

• Applicable Applications for anti-PTPRM antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (12 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 16 amino acid peptide from internal region of human PTPRM. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Bovine, Bat, Horse, Rabbit (100%); Opossum, Chicken (94%).
• Immunogen Type: Synthetic peptide
• Immunogen: PTPRM / PTP Mu antibody was raised against synthetic 16 amino acid peptide from internal region of human PTPRM. Percent identity with other species by BLAST analysis: Human, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Bovine, Bat, Horse, Rabbit (100%); Opossum, Chicken (94%); Elephant, Panda, Dog (88%); Gorilla, Xenopus (81%).
• Antigen Modification: Internal
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-PTPRM antibody IHC of human eye, retina. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-PTPRM antibody

PTP mu, a R2A receptor protein tyrosine phosphatase, is composed of an extracellular segment containing a MAM domain, an immunoglobulin domain and four fibronectin type III repeats, a transmembrane segment, and two intracellular protein phosphatase domains. PTP mu has been shown to affect cell-cell aggregation, regulate cardiac myocyte Kv1.5 channel expression, and promote neurite outgrowth of retinal ganglion cells.

Product Categories/Family for anti-PTPRM antibody

Family: Protein Phosphatase; Subfamily: R2A

NCBI and Uniprot Product Information

• NCBI GI #: 157419150
• NCBI GeneID: 5797
• NCBI Accession #: NP_002836.3
• NCBI GenBank Nucleotide #: NM_002845.3
• UniProt Accession #: P28827; A7MBN1; D3DUH8; J3QL11
• Molecular Weight: 165,060 Da
• NCBI Official Full Name: receptor-type tyrosine-protein phosphatase mu isoform 2
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, M
• NCBI Official Symbol: PTPRM
• NCBI Official Synonym Symbols: RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase mu; protein tyrosine phosphatase mu; protein-tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, mu polypeptide
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase mu
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRM
• UniProt Synonym Gene Names: PTPRL1; Protein-tyrosine phosphatase mu; R-PTP-mu
• UniProt Entry Name: PTPRM_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

PTPRM: a single-pass type I membrane protein involved in cell-cell adhesion through homophilic interactions. A protein-tyrosine phosphatase receptor of the class 2B subfamily. A negative regulator of proliferation and invasion of breast cancer cells. The PTPRM gene is frequently hypermethylated in sporadic cancers. Modulates p120 catenin phosphorylation, promoting adipogenic differentiation. Two isoforms of the human protein have been reported.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.48; Phosphatase; Receptor protein phosphatase, tyrosine

Chromosomal Location of Human Ortholog: 18p11.2

Cellular Component: cell-cell adherens junction; lamellipodium; integral to plasma membrane; perinuclear region of cytoplasm; cytoplasm; intercellular junction

Molecular Function: identical protein binding; protein binding; cadherin binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: response to drug; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; positive regulation of vasodilation; homophilic cell adhesion; protein amino acid dephosphorylation; signal transduction; neurite development; retinal ganglion cell axon guidance