Western Blot (WB)
(Western Blot analysis of A375 and A431 cell using PTPN6 Polyclonal Antibody at dilution of 1:500)
Rabbit PTPN6 Polyclonal Antibody | anti-PTPN6 antibody
PTPN6 Polyclonal Antibody
IHC: 1:50-1:200
Western Blot (WB)
(Western Blot analysis of A375 and A431 cell using PTPN6 Polyclonal Antibody at dilution of 1:500)
Western Blot (WB)
(Western Blot analysis of A375 and A431 cell using PTPN6 Polyclonal Antibody at dilution of 1:500)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colon cancer using PTPN6 Polyclonal Antibody at dilution of 1:35)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human colon cancer using PTPN6 Polyclonal Antibody at dilution of 1:35)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer using PTPN6 Polyclonal Antibody at dilution of 1:35)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer using PTPN6 Polyclonal Antibody at dilution of 1:35)
NCBI and Uniprot Product Information
Uniprot Description
SHP-1: an SH2-containing ubiquitously expressed tyrosine-specific protein phosphatase. Plays a key role in hematopoiesis. Directly links growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Three alternatively spliced isoforms have been described.
Protein type: Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.48
Cellular Component: cytoplasm; nucleolus; alpha-beta T cell receptor complex; intercellular junction; intracellular; nucleus
Molecular Function: protein binding; hydrolase activity; phosphotyrosine binding; phosphoric monoester hydrolase activity; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; SH2 domain binding; protein kinase binding; SH3 domain binding; phosphoprotein phosphatase activity; natural killer cell lectin-like receptor binding
Biological Process: negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of MAP kinase activity; peptidyl-tyrosine phosphorylation; negative regulation of MAPKKK cascade; natural killer cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; positive regulation of cell adhesion mediated by integrin; negative regulation of T cell receptor signaling pathway; signal transduction; protein amino acid dephosphorylation; regulation of release of sequestered calcium ion into cytosol; positive regulation of phosphoinositide 3-kinase cascade; negative regulation of humoral immune response mediated by circulating immunoglobulin; cell proliferation; B cell receptor signaling pathway; negative regulation of T cell proliferation; dephosphorylation; negative regulation of B cell receptor signaling pathway; positive regulation of cell proliferation; regulation of B cell differentiation; abortive mitotic cell cycle; hemopoietic progenitor cell differentiation; platelet formation; cell differentiation
Research Articles on PTPN6
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Product Notes
The PTPN6 ptpn6 (Catalog #AAA2529895) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTPN6 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PTPN6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). WB: 1:200-1:1000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the PTPN6 ptpn6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTPN6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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