Rabbit anti-Human, Mouse PTPN4 Polyclonal Antibody | anti-PTPN4 antibody

PTPN4 Antibody

Cat. Num. AAA9414011

• Gene Names: PTPN4; MEG; PTPMEG; PTPMEG1
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: PTPN4; Polyclonal Antibody; PTPN4 Antibody; MEG; PTPMEG; PTPMEG1; anti-PTPN4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total PTPN4 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.6 mg/ml (varies by lot)
• Sequence Length: 926

• Applicable Applications for anti-PTPN4 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the N terminal of human protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
• Target Name: PTPN4
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/40.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/40.)

Related Product Information for anti-PTPN4 antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins.

Product Categories/Family for anti-PTPN4 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4506295
• NCBI GeneID: 5775
• NCBI Accession #: NP_002821.1
• NCBI GenBank Nucleotide #: NM_002830.3
• UniProt Accession #: P29074; Q9UDA7; B2RBV8
• Molecular Weight: 105,911 Da
• NCBI Official Full Name: tyrosine-protein phosphatase non-receptor type 4
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
• NCBI Official Symbol: PTPN4
• NCBI Official Synonym Symbols: MEG; PTPMEG; PTPMEG1
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 4
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 4
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: PTPN4
• UniProt Synonym Gene Names: MEG; PTPase-MEG1
• UniProt Entry Name: PTN4_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]

Uniprot Description

PTPN4: May act at junctions between the membrane and the cytoskeleton. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm

Molecular Function: protein binding; non-membrane spanning protein tyrosine phosphatase activity; cytoskeletal protein binding

Biological Process: protein amino acid dephosphorylation