Western Blot (WB)
(Mouse Ptk2 Antibody (Center) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Ptk2 antibody detected the Ptk2 protein (arrow).)
Rabbit anti-Mouse Ptk2 Polyclonal Antibody | anti-Ptk2 antibody
Mouse Ptk2 Antibody (Center)
Western Blot (WB)
(Mouse Ptk2 Antibody (Center) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Ptk2 antibody detected the Ptk2 protein (arrow).)
Western Blot (WB)
(Mouse Ptk2 Antibody (Center) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Ptk2 antibody detected the Ptk2 protein (arrow).)
Beverdam, A., et al. Dev. Dyn. 239(10):2735-2741(2010)
Ma, Y., et al. FEBS Lett. 584(18):3949-3954(2010)
Beinke, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16234-16239(2010)
Ashton, G.H., et al. Dev. Cell 19(2):259-269(2010)
NCBI and Uniprot Product Information
Uniprot Description
FAK: a tyrosine kinase of the FAK family required for cell migration and contact-dependent survival signaling. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Downstream of integrins and Src, upstream of Ras/MAPK. Localizes to focal adhesions that form between cells growing in the presence of extracellular matrix constituents. Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with Shb. Required for full Ras transformation of fibroblasts. Increased expression in breast and other cancers, related to chromosome 8q amplification. Overexpression and activation associated with increased migration, invasion and progression of ovarian cancer, and with progression in hepatocellular carcinoma, thyroid cancer, and acute myelogenous leukemia. siRNA increases chemosensitivity of pancreatic adenocarcinoma xenografts. Inhibitor: ISI15421 (antisense). Four splice-variant isoforms have been observed.
Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; TK group; Fak family
Cellular Component: focal adhesion; basolateral plasma membrane; cytosol; nuclear body; extrinsic to internal side of plasma membrane; cytoskeleton; membrane; lamellipodium; cytoplasm; apical plasma membrane; stress fiber; nucleolus; plasma membrane; cell junction; nucleus; sarcolemma
Molecular Function: identical protein binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; actin binding; protein kinase binding; protein kinase activity; transferase activity; integrin binding; JUN kinase binding; signal transducer activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; protein complex binding; phosphoinositide 3-kinase binding; kinase activity; SH2 domain binding; ATP binding; receptor binding
Biological Process: extracellular matrix organization and biogenesis; establishment of nucleus localization; positive regulation of cell adhesion; peptidyl-tyrosine phosphorylation; multicellular organismal development; protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; neuron migration; negative regulation of synaptogenesis; positive regulation of vasodilation; positive regulation of smooth muscle cell migration; protein amino acid phosphorylation; cellular chloride ion homeostasis; positive regulation of synaptic transmission; regulation of cell shape; regulation of cell adhesion mediated by integrin; positive regulation of phagocytosis; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; ephrin receptor signaling pathway; JNK cascade; negative regulation of axonogenesis; angiogenesis; vasculogenesis; negative regulation of cell migration; epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; regulation of cell adhesion; blood vessel development; regulation of osteoblast differentiation; central nervous system neuron axonogenesis; MAPKKK cascade; signal complex assembly; microtubule cytoskeleton organization and biogenesis; negative regulation of organ growth; positive regulation of cell growth; regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of protein kinase activity; endothelial cell migration; innate immune response; negative regulation of cell-cell adhesion; positive regulation of protein amino acid phosphorylation; cell motility; phosphorylation; positive regulation of cell migration; negative regulation of apoptosis
Research Articles on Ptk2
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Product Notes
The Ptk2 ptk2 (Catalog #AAA9203834) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 426-453. The Mouse Ptk2 Antibody (Center) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Ptk2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Ptk2 ptk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ptk2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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