Rabbit PTGES Polyclonal Antibody | anti-PTGES antibody

Anti-PTGES Antibody, Rabbit Polyclonal

Cat. Num. AAA8104036

• Gene Names: PTGES; PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1
• Reactivity: Human; Predicted to React with: Cynomolgus (Species predicted to react based on 100% sequence homology)
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: PTGES; Polyclonal Antibody; Anti-PTGES Antibody; Rabbit Polyclonal; PTGES Antibody; Rabbit PAb; Antigen Affinity Purified; prostaglandin E synthase; Anti-MGST-IV Antibody; Anti-MGST1-L1 Antibody; Anti-MGST1L1 Antibody; Anti-MPGES Antibody; Anti-mPGES-1 Antibody; Anti-PGES Antibody; Anti-PIG12 Antibody; Anti-PP102 Antibody; Anti-PP1294 Antibody; Anti-TP53I12 Antibody; anti-PTGES antibody

• Host: Rabbit
• Reactivity: Human; Predicted to React with: Cynomolgus (Species predicted to react based on 100% sequence homology)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human PTGES
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-PTGES antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the center region of the Human PTGES
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human PTGES, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human PTGES in human placenta with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-PTGES antibody

Prostaglandin E synthase (PTGES, also known as microsomal PGE synthase-1) acts downstream of PTGS2 and is inducibly expressed in most systems. During parturition, inflammatory cytokines promote PGE(2) production through increased prostaglandin-endoperoxide synthase-2 (PTGS2, also known as cyclooxygenase-2) expression. This is mediated, in part, through activation of the transcription factor nuclear factor kappa B (NFkappaB). By coordinately regulating PTGS2 and PTGES, NFkappaB may contribute to an inducible PGE(2) biosynthesis pathway during human parturition. PTGES produces, as part of the prostaglandin pathway, prostaglandin E2 which is a well-known driver for pain and inflammation. This fact together with the observed upregulation of PTGES during inflammation suggests that blockade of the enzyme might provide a beneficial treatment option for inflammation-related conditions such as endometriosis.

References

Wang T, et al. (2019) Stabilization of ptges by deubiquitinase usp9x promotes metastatic features of lung cancer via pge(2) signaling. Am J Cancer Res 9 (6): 1145-1160.Koppitz M, et al. (2019) Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin e synthase-1 for the treatment of endometriosis. Bioorg Med Chem Lett 29 (18): 2700-2705.Ackerman WEt, et al. (2008) Nuclear factor-kappa b regulates inducible prostaglandin e synthase expression in human amnion mesenchymal cells. Biol Reprod 78 (1): 68-76.

NCBI and Uniprot Product Information

• NCBI GI #: 4758910
• NCBI GeneID: 9536
• NCBI Accession #: NP_004869.1
• NCBI GenBank Nucleotide #: NM_004878.4
• UniProt Accession #: O14684; O14900; Q5SZC0
• Molecular Weight: 17,102 Da
• NCBI Official Full Name: prostaglandin E synthase
• NCBI Official Synonym Full Names: prostaglandin E synthase
• NCBI Official Symbol: PTGES
• NCBI Official Synonym Symbols: PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1
• NCBI Protein Information: prostaglandin E synthase; MGST1-like 1; p53-induced gene 12 protein; p53-induced apoptosis protein 12; glutathione S-transferase 1-like 1; microsomal prostaglandin E synthase 1; microsomal prostaglandin E synthase-1; tumor protein p53 inducible protein 12
• UniProt Protein Name: Prostaglandin E synthase
• Protein Family: Prostaglandin E synthase
• UniProt Gene Name: PTGES
• UniProt Synonym Gene Names: MGST1L1; MPGES1; PGES; PIG12; MGST1-L1; MPGES-1
• UniProt Entry Name: PTGES_HUMAN

NCBI Description

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

Uniprot Description

PTGES: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family.

Protein type: EC 5.3.99.3; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Nuclear envelope; Membrane protein, multi-pass; Isomerase

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; nuclear envelope lumen; integral to membrane

Molecular Function: glutathione binding; prostaglandin-E synthase activity

Biological Process: negative regulation of cell proliferation; chronic inflammatory response; response to retinoic acid; response to cytokine stimulus; cyclooxygenase pathway; arachidonic acid metabolic process; response to lipopolysaccharide; response to calcium ion; signal transduction; prostaglandin biosynthetic process; response to organic cyclic substance; acute inflammatory response; prostaglandin metabolic process