Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lung using MBS7603138 (PTAFR antibody) at dilution of 1:50)
Rabbit anti-Human PTAFR Polyclonal Antibody | anti-PTAFR antibody
PTAFR Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lung using MBS7603138 (PTAFR antibody) at dilution of 1:50)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human lung using MBS7603138 (PTAFR antibody) at dilution of 1:50)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Description
PTAFR: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.
Protein type: Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p35-p34.3
Cellular Component: integral to membrane; integral to plasma membrane; intracellular membrane-bound organelle; membrane; nucleoplasm; plasma membrane
Molecular Function: G-protein coupled receptor activity; lipopolysaccharide binding; lipopolysaccharide receptor activity; mitogen-activated protein kinase binding; phospholipid binding; platelet activating factor receptor activity; purinergic nucleotide receptor activity, G-protein coupled
Biological Process: chemotaxis; cytokine production; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; inositol trisphosphate biosynthetic process; lipopolysaccharide-mediated signaling pathway; negative regulation of blood pressure; parturition; phosphoinositide-mediated signaling; positive regulation of interleukin-6 biosynthetic process; positive regulation of neutrophil degranulation; positive regulation of smooth muscle cell proliferation; positive regulation of translation; positive regulation of tumor necrosis factor production; positive regulation of vasoconstriction; positive regulation of vasodilation; regulation of transcription from RNA polymerase II promoter; response to symbiotic bacterium; transcytosis
Research Articles on PTAFR
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Product Notes
The PTAFR ptafr (Catalog #AAA7603138) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTAFR Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PTAFR can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the PTAFR ptafr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTAFR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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