Rabbit anti-Human PSMB6 Polyclonal Antibody | anti-PSMB6 antibody

PSMB6 Antibody (Center)

Cat. Num. AAA9216768

• Gene Names: PSMB6; Y; LMPY; DELTA
• Reactivity: Human
• Applications: Western Blot
• Synonyms: PSMB6; Polyclonal Antibody; PSMB6 Antibody (Center); Purified Rabbit Polyclonal Antibody (Pab); Proteasome subunit beta type-6; Macropain delta chain; Multicatalytic endopeptidase complex delta chain; Proteasome delta chain; Proteasome subunit Y; LMPY; Y; anti-PSMB6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This PSMB6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 151-185 amino acids from the Central region of human PSMB6.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 239

• Applicable Applications for anti-PSMB6 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-PSMB6 Antibody (Center) at 1:2000 dilutionLane 1: Hela whole cell lysateLane 2: Jurkat whole cell lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 25 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-PSMB6 antibody

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the peptidyl glutamyl-like activity. May catalyze basal processing of intracellular antigens.

Product Categories/Family for anti-PSMB6 antibody

Cell Biology

References

Akiyama K.-Y.,et al.Science 265:1231-1234(1994). Bienvenut W.V.,et al.Submitted (DEC-2008) to UniProtKB. DeMartino G.N.,et al.Biochim. Biophys. Acta 1079:29-38(1991). Lee L.W.,et al.Biochim. Biophys. Acta 1037:178-185(1990). Lubec G.,et al.Submitted (MAR-2007) to UniProtKB.

NCBI and Uniprot Product Information

• NCBI GI #: 23110925
• NCBI GeneID: 5694
• NCBI Accession #: NP_002789.1
• NCBI GenBank Nucleotide #: NM_002798.2
• UniProt Accession #: P28072; Q96J55
• Molecular Weight: 25358
• NCBI Official Full Name: proteasome subunit beta type-6 isoform 1
• NCBI Official Synonym Full Names: proteasome subunit beta 6
• NCBI Official Symbol: PSMB6
• NCBI Official Synonym Symbols: Y; LMPY; DELTA
• NCBI Protein Information: proteasome subunit beta type-6
• UniProt Protein Name: Proteasome subunit beta type-6
• Protein Family: Proteasome
• UniProt Gene Name: PSMB6
• UniProt Synonym Gene Names: LMPY; Y
• UniProt Entry Name: PSB6_HUMAN

NCBI Description

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Uniprot Description

PSMB6: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the peptidyl glutamyl-like activity. May catalyze basal processing of intracellular antigens. Belongs to the peptidase T1B family.

Protein type: Proteasome complex; Protease; EC 3.4.25.1

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: proteasome complex; nucleoplasm; Golgi apparatus; proteasome core complex; cytoplasm; cytosol; nucleus

Molecular Function: threonine endopeptidase activity; endopeptidase activity

Biological Process: stimulatory C-type lectin receptor signaling pathway; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; axon guidance; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; nerve growth factor receptor signaling pathway; activation of MAPKK activity; viral reproduction; apoptosis; programmed cell death; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; tumor necrosis factor-mediated signaling pathway; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; small GTPase mediated signal transduction; proteasomal ubiquitin-independent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; vascular endothelial growth factor receptor signaling pathway; G1/S transition of mitotic cell cycle; negative regulation of apoptosis