Western Blot (WB)
(Western blotAll lanes: PSMB3antibody at 3.73ug/mlLane 1 : Hela whole cell lysateLane 2 : MCF7 whole cell lysateLane 3 : HepG-2 whole cell lysateLane 4 : K562 whole cell lysateLane 5 : Jurkat whole cell lysateLane 6 : NIH/3T3 whole cell lysateLane 7 : 293T whole cell lysateSecondaryGoat polyclonal to Rabbit IgG at 1/10000 dilutionPredicted band size: 23 kDaObserved band size: 23 kDa)
Rabbit anti-Human PSMB3 Polyclonal Antibody | anti-PSMB3 antibody
PSMB3 Antibody
Western Blot (WB)
(Western blotAll lanes: PSMB3antibody at 3.73ug/mlLane 1 : Hela whole cell lysateLane 2 : MCF7 whole cell lysateLane 3 : HepG-2 whole cell lysateLane 4 : K562 whole cell lysateLane 5 : Jurkat whole cell lysateLane 6 : NIH/3T3 whole cell lysateLane 7 : 293T whole cell lysateSecondaryGoat polyclonal to Rabbit IgG at 1/10000 dilutionPredicted band size: 23 kDaObserved band size: 23 kDa)
Western Blot (WB)
(Western blotAll lanes: PSMB3antibody at 3.73ug/mlLane 1 : Hela whole cell lysateLane 2 : MCF7 whole cell lysateLane 3 : HepG-2 whole cell lysateLane 4 : K562 whole cell lysateLane 5 : Jurkat whole cell lysateLane 6 : NIH/3T3 whole cell lysateLane 7 : 293T whole cell lysateSecondaryGoat polyclonal to Rabbit IgG at 1/10000 dilutionPredicted band size: 23 kDaObserved band size: 23 kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skin tissue using MBS7045869 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human skin tissue using MBS7045869 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7045869 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human placenta tissue using MBS7045869 at dilution 1:100)
NCBI and Uniprot Product Information
NCBI Description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12. Alternative splicing results in multiple transcript variants [provided by RefSeq, Sep 2013]
Uniprot Description
PSMB3: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Belongs to the peptidase T1B family.
Protein type: EC 3.4.25.1; Cell cycle regulation; Proteasome complex; Protease
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: actin cytoskeleton; cytoplasm; cytosol; Golgi apparatus; mitochondrion; nucleoplasm; nucleus; proteasome complex; proteasome core complex
Molecular Function: protein binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
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Product Notes
The PSMB3 psmb3 (Catalog #AAA7045869) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PSMB3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PSMB3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the PSMB3 psmb3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PSMB3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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