Rabbit PSMA6 Polyclonal Antibody | anti-PSMA6 antibody

PSMA6 Rabbit Polyclonal

Cat. Num. AAA7603098

• Gene Names: PSMA6; IOTA; p27K; PROS27
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry, Immunofluorescence, Western Blot, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PSMA6; Polyclonal Antibody; PSMA6 Rabbit Polyclonal; anti-PSMA6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 227

• Applicable Applications for anti-PSMA6 antibody: ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP)
• Immunogen: Proteasome (prosome, macropain) subunit, alpha type, 6
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lung cancer using MBS7603098 (PSMA6 antibody) at dilution of 1:50)

Western Blot (WB)

(MCF7 cells were subjected to SDS PAGE followed by western blot with MBS7603098 (PSMA6 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 532691774
• NCBI GeneID: 5687
• NCBI Accession #: NP_001269163.1
• NCBI GenBank Nucleotide #: NM_001282234.1
• Molecular Weight: 18,816 Da
• NCBI Official Full Name: proteasome subunit alpha type-6 isoform c
• NCBI Official Synonym Full Names: proteasome subunit alpha 6
• NCBI Official Symbol: PSMA6
• NCBI Official Synonym Symbols: IOTA; p27K; PROS27
• NCBI Protein Information: proteasome subunit alpha type-6
• UniProt Protein Name: Proteasome subunit alpha type-6
• Protein Family: Proteasome
• UniProt Gene Name: PSMA6
• UniProt Synonym Gene Names: PROS27; PROS-27; p27K
• UniProt Entry Name: PSA6_HUMAN

NCBI Description

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

Uniprot Description

PSMA6: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Belongs to the peptidase T1A family.

Protein type: Proteasome complex; Protease; EC 3.4.25.1

Chromosomal Location of Human Ortholog: 14q13

Cellular Component: cytoplasm; cytosol; myofibril; nuclear matrix; nucleoplasm; nucleus; polysome; proteasome complex; proteasome core complex; sarcomere

Molecular Function: endopeptidase activity; NF-kappaB binding; protein binding; RNA binding; threonine endopeptidase activity

Biological Process: activation of NF-kappaB transcription factor; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; proteolysis involved in cellular protein catabolic process; regulation of amino acid metabolic process; regulation of inflammatory response; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway

Disease: Myocardial Infarction, Susceptibility To