Rabbit PSMA2 Polyclonal Antibody | anti-PSMA2 antibody

PSMA2 Rabbit Polyclonal

Cat. Num. AAA7603095

• Gene Names: PSMA2; MU; HC3; PSC2; PMSA2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PSMA2; Polyclonal Antibody; PSMA2 Rabbit Polyclonal; anti-PSMA2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 234

• Applicable Applications for anti-PSMA2 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Immunogen: Proteasome (prosome, macropain) subunit, alpha type, 2
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human esophagus using MBS7603095 (PSMA2 antibody) at dilution of 1:50)

Western Blot (WB)

(Hela cells were subjected to SDS PAGE followed by western blot with MBS7603095 (PMSA2 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 47496581
• NCBI GeneID: 5683
• UniProt Accession #: P25787; Q6ICS6; Q9BU45
• Molecular Weight: 25,899 Da
• NCBI Official Full Name: PSMA2, partial
• NCBI Official Synonym Full Names: proteasome subunit alpha 2
• NCBI Official Symbol: PSMA2
• NCBI Official Synonym Symbols: MU; HC3; PSC2; PMSA2
• NCBI Protein Information: proteasome subunit alpha type-2
• UniProt Protein Name: Proteasome subunit alpha type-2
• Protein Family: Proteasome
• UniProt Gene Name: PSMA2
• UniProt Synonym Gene Names: HC3; PSC3
• UniProt Entry Name: PSA2_HUMAN

NCBI Description

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. [provided by RefSeq, Jul 2008]

Uniprot Description

PSMA2: a proteasomal protein of the T1A peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. The component C3 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.

Protein type: EC 3.4.25.1; Protease; Proteasome complex

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: cytosol; nucleoplasm; nucleus; proteasome complex; proteasome core complex

Molecular Function: protein binding; threonine endopeptidase activity

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; response to virus; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway