Rabbit anti-Human, Mouse PSG3 Polyclonal Antibody | anti-PSG3 antibody

PSG3, NT (PSG3, Pregnancy-specific beta-1-glycoprotein 3, Carcinoembryonic antigen SG5) (FITC)

Cat. Num. AAA6338065

• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PSG3; Polyclonal Antibody; NT (PSG3; Pregnancy-specific beta-1-glycoprotein 3; Carcinoembryonic antigen SG5) (FITC); Carcinoembryonic antigen SG5; anti-PSG3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-PSG3 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: PSG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29~58 amino acids from the N-terminal region of human PSG3.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(PSG3 Antibody (N-term) western blot analysis in MCF-7 cell line and mouse liver,brain tissue lysates (35ug/lane).This demonstrates the PSG3 antibody detected the PSG3 protein (arrow).)

Related Product Information for anti-PSG3 antibody

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).

Product Categories/Family for anti-PSG3 antibody

Antibodies; Carbohydrates; Glycoproteins

References

Colland, F., et al. Genome Res. 14(7):1324-1332(2004). Grimwood, J., et al. Nature 428(6982):529-535(2004). Teglund, S., et al. Genomics 23(3):669-684(1994) Olsen, A., et al. Genomics 23(3):659-668(1994) Shupert, W.L., et al. Mol. Cell. Biochem. 120(2):159-170(1993).

NCBI and Uniprot Product Information

• NCBI GI #: 109240546
• NCBI GeneID: 5671
• NCBI Accession #: NP_066296.2
• NCBI GenBank Nucleotide #: NM_021016.3
• UniProt Accession #: Q16557; Q08265; Q9BRW2; Q9UPL4; Q9UQ77
• Molecular Weight: 47,945 Da
• NCBI Official Full Name: pregnancy-specific beta-1-glycoprotein 3
• NCBI Official Synonym Full Names: pregnancy specific beta-1-glycoprotein 3
• NCBI Official Symbol: PSG3
• NCBI Protein Information: pregnancy-specific beta-1-glycoprotein 3; PSBG-3; PS-beta-G-3; carcinoembryonic antigen SG5; pregnancy-specific glycoprotein 3
• UniProt Protein Name: Pregnancy-specific beta-1-glycoprotein 3
• Protein Family: Pregnancy-specific beta-1-glycoprotein
• UniProt Gene Name: PSG3
• UniProt Synonym Gene Names: PS-beta-G-3; PSBG-3
• UniProt Entry Name: PSG3_HUMAN

NCBI Description

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

Uniprot Description

PSG3: Belongs to the immunoglobulin superfamily. CEA family

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular region

Biological Process: defense response; female pregnancy