Flow Cytometry (FC/FACS)
(Flow cytometric analysis of Hela cells using PSEN2(Presenilin-2 NTF subunit) Antibody (N-term)(green) compared to an isotype control of rabbit IgG(blue). MBS9211943 was diluted at 1:25 dilution. An Alexa Fluor 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.)
Rabbit anti-Human PSEN2 Polyclonal Antibody | anti-PSEN2 antibody
PSEN2 Antibody (N-term)
WB~~1:1000
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of Hela cells using PSEN2(Presenilin-2 NTF subunit) Antibody (N-term)(green) compared to an isotype control of rabbit IgG(blue). MBS9211943 was diluted at 1:25 dilution. An Alexa Fluor 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.)
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of Hela cells using PSEN2(Presenilin-2 NTF subunit) Antibody (N-term)(green) compared to an isotype control of rabbit IgG(blue). MBS9211943 was diluted at 1:25 dilution. An Alexa Fluor 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.)
Western Blot (WB)
(Western blot analysis of lysate from Hela cell line, using PSEN2(Presenilin-2 NTF subunit) Antibody (N-term). MBS9211943 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.)
Western Blot (WB)
(Western blot analysis of lysate from Hela cell line, using PSEN2(Presenilin-2 NTF subunit) Antibody (N-term). MBS9211943 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.)
Rogaev E.I.,et al.Nature 376:775-778(1995).
Li J.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:12180-12184(1995).
Levy-Lahad E.,et al.Genomics 34:198-204(1996).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
NCBI and Uniprot Product Information
NCBI Description
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
PSEN2: probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). An integral membrane protein of the Golgi and endoplasmic reticulum. Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. Two alternative splice isoforms have been identified.
Protein type: Membrane protein, multi-pass; EC 3.4.23.-; Cell surface; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 1q42.13
Cellular Component: Golgi apparatus; centrosome; cell surface; lysosomal membrane; integral to plasma membrane; nuclear inner membrane; cytosol; lipid raft; ciliary rootlet; kinetochore; membrane; cell soma; perinuclear region of cytoplasm; apical plasma membrane; mitochondrial inner membrane; dendritic shaft; neuromuscular junction; endoplasmic reticulum membrane; protein complex; endoplasmic reticulum; cell cortex; Z disc; Golgi membrane; growth cone; axon; plasma membrane
Molecular Function: protein binding; endopeptidase activity; aspartic-type endopeptidase activity
Biological Process: positive regulation of catalytic activity; axon guidance; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; protein maturation; regulation of synaptic plasticity; positive regulation of coagulation; cell fate specification; T cell receptor signaling pathway; T cell activation during immune response; protein transport; amyloid precursor protein catabolic process; hair follicle development; negative regulation of protein amino acid phosphorylation; calcium ion transport; beta-amyloid metabolic process; forebrain development; ephrin receptor signaling pathway; brain morphogenesis; negative regulation of protein binding; dorsoventral neural tube patterning; cardiac muscle contraction; embryonic limb morphogenesis; Notch signaling pathway; somitogenesis; membrane protein intracellular domain proteolysis; thymus development; regulation of epidermal growth factor receptor activity; membrane protein ectodomain proteolysis; Notch receptor processing; memory; endoplasmic reticulum calcium ion homeostasis; myeloid leukocyte differentiation; response to hypoxia; protein processing; hemopoietic progenitor cell differentiation; alveolus development; negative regulation of protein complex assembly; negative regulation of apoptosis
Disease: Alzheimer Disease 4; Cardiomyopathy, Dilated, 1v
Research Articles on PSEN2
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Product Notes
The PSEN2 psen2 (Catalog #AAA9211943) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PSEN2 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PSEN2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS). FC~~1:25 WB~~1:1000. Researchers should empirically determine the suitability of the PSEN2 psen2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PSEN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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