Rabbit anti-Human PRSS7 Polyclonal Antibody | anti-PRSS7 antibody

PRSS7, CT (E979) (TMPRSS15, ENTK, PRSS7, Enteropeptidase, Enterokinase, Serine protease 7, Transmembrane protease serine 15, Enteropeptidase non-catalytic heavy chain, Enteropeptidase catalytic light chain) (MaxLight 490)

Cat. Num. AAA6337969

• Gene Names: TMPRSS15; ENTK; PRSS7
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Western Blot, Immunohistochemistry
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PRSS7; Polyclonal Antibody; CT (E979) (TMPRSS15; ENTK; Enteropeptidase; Enterokinase; Serine protease 7; Transmembrane protease serine 15; Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain) (MaxLight 490); TMPRSS15; Enteropeptidase catalytic light chain; anti-PRSS7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PRSS7.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-PRSS7 antibody: Flow Cytometry (FC/FACS), Western Blot (WB), FLISA, Immunohistochemistry (IHC) Paraffin
• Application Notes: FC/FACS: 1:10-1:50; WB: 1:1000; IHC-P: 1:10-1:50; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 964-994 in the C-terminal region of human PRSS7, UniProt Accession #NP_002763.
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-PRSS7 antibody

Antibodies; Transmembrane Proteins

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Nakanishi, J., et al. J. Invest. Dermatol. 130(4):944-952(2010). Vilen, S.T., et al. Exp. Cell Res. 314(4):914-926(2008). Imamura, T., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 285 (6), G1235-G1241 (2003): Holzinger, A., et al. Am. J. Hum. Genet. 70(1):20-25(2002).

NCBI and Uniprot Product Information

• NCBI GI #: 223942069
• NCBI GeneID: 5651
• NCBI Accession #: NP_002763.2
• NCBI GenBank Nucleotide #: NM_002772.2
• UniProt Accession #: P98073; Q2NKL7
• Molecular Weight: 112,935 Da
• NCBI Official Full Name: enteropeptidase
• NCBI Official Synonym Full Names: transmembrane protease, serine 15
• NCBI Official Symbol: TMPRSS15
• NCBI Official Synonym Symbols: ENTK; PRSS7
• NCBI Protein Information: enteropeptidase
• UniProt Protein Name: Enteropeptidase
• UniProt Gene Name: TMPRSS15
• UniProt Synonym Gene Names: ENTK; PRSS7
• UniProt Entry Name: ENTK_HUMAN

Uniprot Description

PRSS7: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. Defects in TMPRSS15 are a cause of enterokinase deficiency (ENTKD); a life-threatening intestinal malabsorption disorder characterized by diarrhea and failure to thrive. Belongs to the peptidase S1 family.

Protein type: EC 3.4.21.9; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 21q21.1

Cellular Component: brush border

Molecular Function: protein binding

Disease: Enterokinase Deficiency