Rabbit anti-Human PRRG1 Polyclonal Antibody | anti-PRRG1 antibody

PRRG1, NT (PRRG1, PRGP1, TMG1, Transmembrane gamma-carboxyglutamic acid protein 1, Proline-rich gamma-carboxyglutamic acid protein 1) (AP)

Cat. Num. AAA6337809

• Gene Names: PRRG1; PRGP1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PRRG1; Polyclonal Antibody; NT (PRRG1; PRGP1; TMG1; Transmembrane gamma-carboxyglutamic acid protein 1; Proline-rich gamma-carboxyglutamic acid protein 1) (AP); Proline-rich gamma-carboxyglutamic acid protein 1; anti-PRRG1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
• Sequence Length: 218

• Applicable Applications for anti-PRRG1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: PRRG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-59 amino acids from the N-terminal region of human PRRG1.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(PRRG1 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the PRRG1 antibody detected the PRRG1 protein (arrow).)

Related Product Information for anti-PRRG1 antibody

This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].

Product Categories/Family for anti-PRRG1 antibody

Antibodies; Transmembrane Proteins

References

Lamesch, P., et al. Genomics 89(3):307-315(2007). Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006). Ross, M.T., et al. Nature 434(7031):325-337(2005). Kulman, J.D., et al. Proc. Natl. Acad. Sci. U.S.A. 94(17):9058-9062(1997).

NCBI and Uniprot Product Information

• NCBI GI #: 291219878
• NCBI GeneID: 5638
• NCBI Accession #: NP_001166960.1
• NCBI GenBank Nucleotide #: NP_001166960.1
• UniProt Accession #: O14668
• NCBI Official Full Name: transmembrane gamma-carboxyglutamic acid protein 1 isoform 1
• NCBI Official Synonym Full Names: proline rich and Gla domain 1
• NCBI Official Symbol: PRRG1
• NCBI Official Synonym Symbols: PRGP1
• NCBI Protein Information: transmembrane gamma-carboxyglutamic acid protein 1
• UniProt Protein Name: Transmembrane gamma-carboxyglutamic acid protein 1
• Protein Family: Transmembrane gamma-carboxyglutamic acid protein
• UniProt Gene Name: PRRG1
• UniProt Synonym Gene Names: PRGP1; TMG1; Proline-rich Gla protein 1
• UniProt Entry Name: TMG1_HUMAN

NCBI Description

This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

Uniprot Description

Subcellular location: Membrane; Single-pass type I membrane protein

Potential.

Tissue specificity: Highly expressed in the spinal cord.

Post-translational modification: Gla residues are produced after subsequent post-translational modifications of glutamate by a vitamin K-dependent gamma-carboxylase.

Sequence similarities: Contains 1 Gla (gamma-carboxy-glutamate) domain.