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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human gliomas tissue slide using MBS7603045 (PrP Antibody) at dilution of 1:200)

Rabbit PrP Polyclonal Antibody | anti-PrP antibody

PrP Rabbit Polyclonal

Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Synonyms
PrP; Polyclonal Antibody; PrP Rabbit Polyclonal; anti-PrP antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Form/Format
Liquid
Sequence Length
256
Applicable Applications for anti-PrP antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Immunogen
Prion protein
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gliomas tissue slide using MBS7603045 (PrP Antibody) at dilution of 1:200)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human gliomas tissue slide using MBS7603045 (PrP Antibody) at dilution of 1:200)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7603045 (PrP Antibody) at dilution of 1:1000)

Western Blot (WB) (mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7603045 (PrP Antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

NCBI GI #
UniProt Accession #
Molecular Weight
27,915 Da
NCBI Official Full Name
PrP
UniProt Protein Name
Major prion protein
UniProt Gene Name
PRNP
UniProt Synonym Gene Names
PRP; SIP; PrP
UniProt Entry Name
PRIO_SHEEP

Uniprot Description

Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains ().

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Product Notes

The PrP prnp (Catalog #AAA7603045) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PrP Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PrP can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the PrP prnp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PrP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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